氟喹诺酮类药物在结核病治疗中的研究进展

Research on Fluoroquinolones in the Treatment of Tuberculosis

氟喹诺酮类药物是临床治疗中常用的抗生素种类,其抗菌谱较广,且具有较强的杀菌效果。近年来,有许多国内研究发现氟喹诺酮类药物对于肺结核杆菌的灭菌效果较好,因此,该药物越来越广泛地应用于肺结核的临床治疗,取得了较好效果的同时也存在着一定的不合理用药情况,影响治疗效果和患者身体健康。本文就近几年来我国对于氟喹诺酮类药物治疗结核病的相关研究进展进行综述,主要包括氟喹诺酮类药物治疗初治结核病、复治结核病和耐多药结核病的应用效果以及不同种类氟喹诺酮类药物对结核病的疗效,为结核病的治疗提供一定的参考和依据。

Fluoroquinolone is a commonly used antibiotic type in clinical treatment, and has a broad antibacterial spectrum and a strong bactericidal effect. In recent years, many domestic studies have found that fluoroquinolones have better sterilization effect on tuberculosis bacilli. Therefore, the drug is more and more widely used in the clinical treatment of tuberculosis, and it has achieved good results. Unreasonable medication, affecting the treatment effect and the health of the patient. This article reviews recent research progress in the treatment of tuberculosis with fluoroquinolones in China, including the application of fluoroquinolone in the treatment of newly diagnosed tuberculosis, retreatment of tuberculosis and multidrug-resistant tuberculosis, and the different types of fluoroquinolones for tuberculosis. The efficacy of the treatment provides a certain reference and basis for the treatment of tuberculosis.