摘要
Flupyrimin是由Meiji Seika Pharma发现的作用于烟碱乙酰胆碱受体的新型杀虫剂。为研究其合成方法与生物活性,以2-胺基吡啶、三氟乙酸酐和2-氯-5-氯甲基吡啶为原料制备了Flupyrimin,并经液相-质谱和核磁等表征确证了其结构。生物活性研究结果表明, Flupyrimin具有较好的杀虫活性。
Flupyrimin is a novel insecticide acting on nicotinic acetylcholine receptors discoveried by Meiji Seika Pharma. In order to study the synthesis and biological activities, Flupyrimin was synthesized using 2-aminopyridine,trifluoroacetic anhydride and 2-chloro-5-chloromethylpyridine as starting materials, and its structure was confirmed by1 H NMR and HPLC-MS etc. The bioassay showed that Flupyrimin exhibited good insecticidal activity.
作者
张宁
柳爱平
任叶果
周春格
成淑芬
项军
刘兴平
刘民华
黄明智
兰支利
ZHANG Ning;LILJ Ai-ping;REN Ye-guo;ZHOU Chun-ge;CHENG Shu-fen;XIANG Jun;LIU Xing-pin;LIU Min-hiu;HUANG Ming-zhi;LAN Zhi-li(Hunan Normal University, Changsha 410081,China;NationalEngineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry, Changsha 410014, China;Hunan Province Key Laboratory for Agrochemicals, Changsha 410014, China;HUNAN J&F TEST Co.,Ltd., Changsha 410014, China)
出处
《精细化工中间体》
CAS
2018年第6期12-14,共3页
Fine Chemical Intermediates
基金
国家自然科学基金项目(21672057)
