多脏器功能障碍综合征中肠外营养相关肝损害的研究进展

Research progress of parenteral nutrition associated liver damage in multiple organ dysfunction syndrome

多脏器功能障碍综合征(multiple organ dysfunction syndrome,MODS)患者或因感染等因素发生肠衰竭,肠道功能损害无法完成营养物质、电解质的吸收,重症患者进行性营养不良通常发展迅速,尽早肠外营养可以明显改善MODS患者的预后,现在肠外营养广泛应用于各类重症患者,然而肠外营养所引起的肠外营养相关肝损害(parenteral nutrition-associated liver disease,PNALD)在此类患者中普遍存在。PNALD的出现增加了对患者疾病的治愈难度。许多研究发现营养液中添加ω-3鱼油脂肪乳剂是预防与改善PNALD的有效手段。

Multiple organ dysfunction syndrome(MODS)patients or intestinal failure due to infection and other factors,intestinal dysfunction can not complete the absorption of nutrients and electrolytes.Progressive malnutrition in severe patients usually develops rapidly.Early parenteral nutrition can significantly improve the prognosis of MODS patients.PN is now widely used in all kinds of severe patients,but parenteral nutrition-associated liver disease(PNALD)caused by parenteral nutrition is prevalent in such patients.The emergence of PNALD increases the difficulty of curing patientsz diseases.Many studies have found thatw-3fish oil fat emulsion in nutrient solution is an effective way to prevent and improve PNALD.