磷酸型化合物设计合成方法研究进展

Research Advance in Design and Synthesis Methods of Compounds Based on Phosphoric Acid

磷元素作为"生命活动的调控中心"而备受关注,磷化合物凭借优异的性能及在众多领域的广泛应用,吸引着许多科学家在磷化合物设计、合成与性能方面开展了大量、深入和系统的研究工作,在高端日化、医药卫生以及生命科学等理论与应用方面取得丰硕的成果。但原子经济性、产业化应用、环境友好性以及绿色产业化方面有待进一步提高。在近年来研究基础上,系统地综述了设计合成磷化合物的Kabachnik-Fields反应、Atherton-Todd反应、Abramov反应等及反应机理,为构筑新型磷酸酯型化合物、开发该类化合物的新功能提供重要参考,同时对含磷化合物在三次采油、航空航天等应用领域的发展趋势进行了展望。

Phosphorus has attracted much attention as a "regulatory center for life activities". The excellent performance of phosphorus compounds and its wide application in many fields have attracted many scientists to carry out extensive, in-depth and systematic research work on the design, synthesis and performance of phosphorus compounds.High-end daily, medical and health sciences and life sciences have achieved fruitful results in theory and application. However, the aspects of atomic economy, industrial application, environmental friendliness and green industrialization need to be further improved. Based on recent studies, this paper systematically reviews the Kabachnik-Fields reaction, Atherton-Todd reaction and other reaction mechanisms for the design and synthesis of phosphorus compounds. Provide an important reference for constructing new phosphate ester compounds and developing new functions for such compounds. At the same time, the development trend of phosphorus-containing compounds in tertiary oil recovery, aerospace and other application fields is prospective.