ClC-3在子宫内膜异位症中的研究进展

Research progress of Cl C-3 in endometriosis

氯离子通道3(Cl C-3)是由CLCN3基因编码,电压门控成员Cl2通道超家族的一员,并涉及到调节电活动、细胞体积、增殖、迁移、侵袭、凋亡和细胞内p H,成为目前研究的热点。近年来Cl C-3在妇科疾病中的研究日益增多,本文将对Cl C-3与妇科良恶性疾病,尤其是对Cl C-3与子宫内膜异位症发生发展相关的研究进展进行综述。

Chloride Channel-3 (ClC-3) is a member of the Cl2 channel superfamily, which is encoded by CLCN3 gene. It involves regulating electrical activity, cell volume, proliferation, migration, invasion, apoptosis and intracellular pH, which have become a hot spot of current research. In recent years, the research of ClC-3 in gynecological diseases is increasing day by day. This article will review the research progress of ClC-3 and benign and malignant gynecological diseases, especially the relationship between ClC-3 and the occurrence and development of endometriosis.