循环肿瘤细胞检测对肝细胞肝癌的诊断及监测的临床价值

Clinical values of circulating tumor cells in the diagnosis and surveillance of hepatocellular carcinoma

肝细胞肝癌(HCC)早期即可侵犯血管形成远处转移,患者预后差。HCC的早期诊断及术后监测对提高HCC患者的生存时间尤为重要。循环肿瘤细胞(CTCs)检测作为"液体活检"技术,能够实时重复监测外周血中的肿瘤细胞,对HCC患者的早诊、早治、预后监测及制定个体化精准医疗方案等具有重要临床意义。本文回顾性分析了CTCs国内外研究进展,对其生物学特性、检测方法及在HCC患者诊断、预后等方面的应用价值等进行了系统综述。

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. The prognosis of HCC patients is very poor due to the facts that vascular invasion and distance metastasis may occur in the earlier phase of the cancer. Therefore, it is very important to make earlier diagnosis and timely monitoring post-operatively to ensure the longer survival of HCC patients. Detection of circulating tumor cells (CTCs), as an liquid biopsy, which can detect the tumor cells timely and repeatedly in the circulation, plays an important role in the earlier diagnosis, treatment, monitoring, and making individualized therapeutic plan, etc. In this article, we retrospectively reviewed the current literatures to evaluate the values of CTCs in the diagnosis, therapy, and surveillance of HCC patients in order to guide the clinical practice.