中医药干预老年性痴呆前状态疗效探析

Analysis of the Curative Effect of Traditional Chinese Medicine on Intervention of Pre-state of Alzheimer Disease

目的观察中药复方治疗轻度认知损害(MCI)的效果。方法选取100例MCI患者,按随机数字表法分为治疗组和对照组,各50例。治疗组予中药复方治疗,对照组予安慰剂治疗,疗程均为12周,比较治疗效果。用药前后记录蒙特利尔认知评价量表(Mo CA),日常生活能力(ADL)评分。结果治疗组Mo CA评分显著升高(P <0.05),对照组评分显著降低(P <0.05),2组比较差异有统计学意义(P <0.05)。ADL评分治疗组与对照组无明显差异(P> 0.05)。结论中药复方治疗MCI有一定的效果,且安全性较好。

Objective To observe the effect of traditional Chinese medicine compound on mild cognitive impairment (MCI). Methods 100 MCI patients were randomly divided into treatment group and control group according to the digital grouping, 50 in each group. The treatment group was treated with Chinese medicine compound, and the control group was treated with placebo. Both groups were treated for 12 weeks. The scores of MoCA and ADL were recorded before and after treatment. Results MoCA scores in the treatment group were significantly increased (P<0.05), while those in the control group were significantly decreased (P<0.05). The difference between the two groups was statistically significant (P<0.05). There was no significant difference in ADL score between the treatment group and the control group (P>0.05). Conclusion The Chinese medicine compound is effective and safe in treating mild cognitive impairment.