肥大细胞在深低温停循环肠损伤作用机制中的研究进展

Research progress of mast cells in the mechanism of intestinal injury caused by deep hypothermic circulatory arrest

深低温停循环(deep hypothermic circulatory arrest,DHCA)是外科复杂心脏手术的一种重要辅助技术,是术中脑保护的措施之一,并为外科手术提供便利的操作条件。然而这项技术所导致的并发症也不容忽视,其中肠损伤的发生虽较为隐匿,但是给患者带来巨大的痛苦并明显降低术后生活质量。研究表明,DHCA导致肠道发生缺血再灌注损伤,引起肥大细胞活化释放炎性介质,破坏肠黏膜上皮屏障,最终导致肠损伤。本文就肥大细胞在DHCA肠损伤作用机制中的研究进展做一综述。

Deep hypothermic circulatory arrest(DHCA)is an important assistant technique for complex cardiac surgery,which creates convenient operating conditions for surgery,and is also one of the measures to protect the brain during operation.However,the complications caused by this technique cannot be ignored,and it should be noticed that the occurrence of intestinal injury is relatively insidious,but brings great pain to patients and significantly reduces the quality of life after operation.Studies have shown that intestinal ischemia-reperfusion injury is induced by DHCA.It causes mast cells to activate and release many inflammatory mediators that destroy the intestinal mucosal epithelium barrier,and eventually lead to intestinal injury.This article reviewed the research progress of mast cells in the mechanism of DHCA-induced intestinal injury.