骨形成蛋白-4对于肺动脉高压患者肺血管重构作用的研究进展

Research progress of bone morphogenetic protein-4 in pulmonary vascular remodeling in patients with pulmonary hypertension

肺动脉高压是一大类以肺动脉压力增高,伴或不伴小肺动脉病变为特征的肺血管疾病,其最终可导致患者右心功能衰竭甚至死亡,肺动脉高压已成为威胁人类身心健康的严重疾病。肺动脉高压发病机制多种多样,目前尚无确切定论,但是对遗传性肺动脉高压的研究发现,骨形成蛋白信号系统参与了肺动脉高压的发生发展。本文将对骨形成蛋白-4(BMP4)在肺动脉高压发生发展中的作用以及相关研究进展进行简要综述。

Pulmonary hypertension is a disease characterized by pulmonary artery pressure increased,with or without small artery pathological change,which ultimately leads to right heart failure or even death.Pulmonary hypertension seriously threatens to human health,however,the pathogenesis of pulmonary hypertension is unclear.Previous studies have found that bone morphogenetic protein(BMP)signaling system played an important role in the progress of pulmonary hypertension.In the current review,we describe the mechanism of BMP4 in the development of pulmonary hypertension.