酸枣仁汤中枢药理实验研究进展

Research Progress of Pivot Pharmacological Experiment of Sour Jujube Decoction

近年来,诸多学者运用不同的实验方法对酸枣仁汤进行了深入广泛的基础研究,这些研究成果为我们深入认识和透彻了解酸枣仁汤的中枢药理作用和机制提供了途径。笔者对酸枣仁汤近5年的基础实验文献进行了归类分析,排除酸枣仁单成分及与临床相关的研究文献,对酸枣仁汤的中枢药理作用进行了概括和总结。酸枣仁汤的中枢药理作用有镇静催眠、抗焦虑、抗抑郁、改善记忆、脑保护等作用,这些研究从动物、细胞及分子层次解释了酸枣仁汤的作用机制。作为中药复方,酸枣仁汤通过多组分、多靶点协同作用,从综合和整体的角度对多种中枢神经系统疾病表现出药理作用,并具有良好疗效。酸枣仁汤作为中医治疗失眠的经典方剂,对其进行更深层次的开发可作为新药研发的方向以便对其进行更好地利用。

The pivot pharmacological effects of Sour Jujube Decoction include sedation and hypnosis,anti-anxiety,anti-depression,memory improvement and brain protection.These studies explain the mechanism of action of Sour Jujube Decoction from animal,cell and molecular levels.As a TCM compound,Sour Jujube Decoction shows pharmacological effects on a variety of central nervous system diseases from a comprehensive and holistic point of view through multi-component and multi-target synergy,and has good curative effect.In the current society,the incidence of insomnia,anxiety and depression is increasing,but now widely used western medicine for insomnia,such as benzodiazepines,has adverse reactions such as muscle relaxation,hangover,dependence and so on.Therefore,it is of great social significance to constantly search for more safe and effective sleep regulation drugs.TCM has a long history of insomnia treatment,with remarkable curative effect and little side effects.Sour Jujube Decoction,as a classical prescription of TCM for insomnia,can be further developed as a direction of new drug research and development in order to make better use of it.