肝内胆管癌分子水平研究进展

Progress of molecular profiling of intrahepatic cholangiocarcinoma

肝内胆管癌(ICC)是位于2级胆管以上胆管上皮的恶性肿瘤,术后易复发、化疗效果不明确,远期生存率不高。ICC目前缺乏特异性早期诊断标志物,确诊时往往已是中晚期或者晚期。随着对ICC分子水平的深入研究,发现了一些关键调节子如抑癌基因p53、p16,原癌基因Ras以及miRNA和组蛋白的修饰等,这些调节因子可能成为治疗靶点。笔者就DNA-RNA-蛋白质中心法则为线索对ICC分子水平研究进展进行综述。

Intrahepatic cholangiocarcinoma(ICC)is an epithelial cancer arising above the second-order bile ducts,and is characterized by high tendency to postoperative recurrence,unclear benefit of chemotherapy and low long-term survival rates.At present,there is lack of specific markers for early diagnosis of ICC,so it is always diagnosed at a mid-late or late stage.With the in-depth study of the molecular pathogenesis of ICC,some key regulators such as antioncogenes p53 and p16,proto-oncogenes Ras,and miRNA and histone modifications have been found,which may become the therapeutic targets.Here,the authors address the research progress on the molecular profiling of ICC based on the DNA-RNA-protein central dogma.