血清H_2S水平与骨密度的相关性初步研究

Preliminary study of the correlation between serum H_2S and bone mineral density

目的血清H_2S水平与骨质疏松的相关性。方法收集2015年10月至2017年10月112例在江苏昆山地区体检和门诊就诊人员的资料,其中男82例,女30例,年龄25～86岁,平均(51.40±10.60)岁;采用DEXA骨密度仪检测该人群的骨密度,以及采用亚甲基蓝法测定血清H_2S水平。结果体内血清H_2S水平与髋部骨密度呈正相关,与腰椎骨密度无明显相关性。结论血清H_2S水平与髋部骨密度存在相关,可能是髋部骨密度下降的独立危险因素,H_2S可能是骨密度的保护因素。

Objective To study the correlation between serum H2S and osteoporosis. Methods From October 2015 to October 2017, 112 cases were collected from individuals attended physical examination or clinics in Jiangsu Kunshan area, 82 cases were male, 30 were female, age ranged 25-86 years, with an average of 51.40±10.60 years. Bone mineral density(BMD) was measured by dual-energy x-ray absorptiometry(DEXA), and the methylene blue method was used for the determination of serum H2S levels. Results Serum H2S levels positively correlated with BMD at the hip, but had no significant correlation with BMD at the spine. Conclusion Serum H2S level is associated with hip bone mineral density, thus could be an independent risk factor for the decrease of bone density in the hip, and H2S may also be a protective factor for bone density.