肠道菌群与肥胖发生机制及干预研究进展

Research progress on intestinal microbiota in mechanism of obesity and intervention strategies

肥胖与超重是导致慢性代谢紊乱的主要病因,具有促进多种其他慢性疾病发生的倾向,也可以引起多系统的疾病及增加肿瘤的发生率。目前肠道菌群被认为是这些代谢性疾病发生的危险因素之一。肥胖人群存在肠道菌群结构和功能失调及多样性减少,对肠道菌群进行干预可预防或控制体重增加及机体代谢异常。本文就此进展进行综述。

Obesity may lead to multi -systemic disorders and other chronic disease , as well as causing increased incidence of tumors. The intestinal microbiota has come to be considered as one of risk factors for the development of metabolic diseases. Obesity is associated with gut microbiota compositional and functional alterations. Intestinal microbiota interventions may prevent and control body weight and metabolic dysfunction. The research progress on these aspects are reviewed in this article.