多模态MRI在高级别脑胶质瘤放疗中的应用

The application of multimodal MRI in radiotherapy for patients with high-grade glioma

放疗是高级别脑胶质瘤治疗的重要手段之一;目前,对于利用定位CT和常规MRI图像进行靶区勾画的范围仍然没有统一标准随着影像学技术的不断发展,研究者们发现利用多模态MRI包括氢质子磁共振波谱分析(1H-MRS).BOLD-fMRI (血氧水平依赖性功能磁共振)、弥散加权成像(DWI)、弥散张量成像(DTI)等可更有效地评估肿瘤的浸润范围及定位周围重要组织,从而作为一种补充手段应用于靶区勾画和保护危及器官之中:此外?多模态MRI对评估放疗疗效、探测放射损伤及鉴别真假性进展也有一定作用:文章就多模态MR1在高级别脑胶质瘤术后放疗中应用作一综述.

Radiotherapy is one of the most important treatments of high-grade gliomas ( HGG). Currently, there has been no consensus on the standards for the delineation of the gross tumor volume ( GTV) based on the simulated computed tomography ( CT) scanning and conventional nuignetic resonance imaging (MRI).As the radiological technology advances, researchers have found that the application of multimodal MRI including 1 H magnetic resonance spectroscopy ( 1 H-MRS), blood oxygenation level dependent functional MRI (BOLD-fMRl), diffusion-weighted MRI ( DWI) and diffusion tensor imaging ( DTI) can evaluate the range of HGG invasion and locate the surrounding vital tissues, thereby serving as a supplement for the delineation of target volume and protection of orgiins at risk. Moreover, multimodal MRI can be utilized to evaluate the clinical efficacy of radiotherapy, detect the radiation-induced injury and differentiate the progressive disease from pseudoprogression, hi this article, the application of niultiniodal MRI in the postoperative radiotherapy for patients with high-grade glioma was reviewed.