Engineering vascularized skeletal muscle tissue with transcriptional factor ETV2-induced autologous endothelial cells

Dear Editor,Newly engineered tissues often fail to function due to insufficient blood vessels formation.Autologous vascular endothelial cells are ideal sources for tissue engineering but are often of limited availability.We first identified that transcriptional factor Etv2(ets variant 2,initially named as Etsrp)was specifically expressed in the zebrafish vascular endothelial cells and was required for vascular development in zebrafish(Sumanas and Lin,2006).