红系增生髓系肿瘤的诊断分类演变

Advances in diagnostic classification of erythroid proliferations in myeloid neoplasms

红系增生髓系肿瘤(MN-EP)是一组异质性疾病,以骨髓中有核红细胞增殖、无效造血为主要特点。最初,法、美、英分型(FAB分型)依据形态学标准对MN-EP进行诊断分类。但随着流式细胞术、细胞遗传学及分子生物学技术的发展,FAB分型存在明显不足,不能满足临床需求。因此,世界卫生组织(WHO)分类出台了更准确的诊断分类标准,并对其进行了多次修订。文章对MN-EP诊断分类演变作一综述。

Erythroid proliferations in myeloid neoplasms (MN-EP) is a group of heterogeneous diseases characterized by nucleated red blood cell proliferation and ineffective hematopoiesis in the bone marrow. Initial French-American-British (FAB) classification was used to diagnose and classify MN-EP according to morphological criteria. However, with the development of flow cytometry, cytogenetics and molecular biology techniques, FAB classification is obviously insufficient, which can not meet the clinical needs. Therefore, the World Health Organization (WHO) classification has introduced more accurate diagnostic classification standards and revised them several times. This paper reviews the research progress of MN-EP diagnostic classification.