小儿豉翘清热颗粒治疗急性上呼吸道感染的临床疗效观察

Clinical efficacy of Xiao er Chiqiaoqingre granule in the treatment of acute upper respiratory tract infection

目的探讨小儿豉翘清热颗粒治疗急性上呼吸道感染的临床疗效及安全性。方法选取台州市中西医结合医院自2017年1-12月收治的116例罹患上呼吸道感染的患儿,根据治疗方案不同均分为对照组和观察组,对照组给予利巴韦林颗粒、布洛芬混悬滴剂进行治疗,观察组在此基础上加用小儿豉翘清热颗粒,两组均连续治疗5d,考察并比较两组的临床疗效、临床症状改善情况、治愈时间、血清细胞因子水平及不良反应发生率等。结果经治疗后,观察组痊愈率96.6%与对照组痊愈率81.0%比较,差异有统计学意义(P<0.05);观察组的退热时间、咳嗽消退时间、痊愈时间分别为(1.4±0.5)d、(2.1±0.4)d、(4.5±1.4)d、对照组分别为(2.6±0.9)d、(3.4±1.1)d、(5.8±1.9)d,两组比较,差异均有统计学意义(P<0.05),观察组咽部红肿消退时间为(3.5±1.1)d,对照组为(3.8±1.3)d,两组比较,差异无统计学意义(P>0.05);观察组血清细胞因子IL-6、IL-10和TNF-α水平分别为(108.45±25.61)μg/L、(34.88±9.07)μg/L、(1.26±0.86)mg/mL,对照组分别为(129.27±28.31)μg/L、(43.27±10.09)μg/L、(2.11±1.03)mg/mL,两组比较差异均有统计学意义(P<0.05);两组均未出现其它严重的不良反应。结论小儿豉翘清热颗粒用于治疗急性上呼吸道感染,可显著改善临床症状,增强临床疗效,且安全性较好,有一定的临床借鉴价值。

Objective To investigate the clinical efficacy and safety of Xiao'er Chiqiaoqingre granule in the treatment of acute upper respiratory tract infection.MethodsFrom January 2017 to December 2017,a total of 116 children with upper respiratory tract infection in Taizhou Integrated Traditional Chinese and Western Medicine Hospital were selected and randomly divided into control group and observation group according to different treatment regimens,with 58 cases in each group.The control group was given ribavirin granules,ibuprofen suspension drops for treatment.The observation group was given Xiao'er Chiqiaoqingre granule on the basis of the control group.The two groups were treated for 5 days,then the clinical effect,the improvement of clinical symptoms,the time of cure,the level of serum cytokines and safety were compared between the two groups.ResultsAfter treatment,the cure rate of the observation group was 96.6%,which was significantly higher than 81.0%of the control group(P<0.05).The antipyretic time,cough disappeared time,healing time in the observation group were(1.4±0.5)d,(2.1±0.4)d,(4.5±1.4)d,respectively,which were significantly shorter than those in the control group[(2.6±0.9)d,(3.4±1.1)d,(5.8±1.9)d](all P<0.05).The throat irritation subsided time of the observation group was(3.5±1.1)d,which of the control group was(3.8±1.3)d,the difference was not statistically significant(P>0.05).The serum levels of IL-6,IL-10 and TNF-in the observation group were(108.45±25.61)μg/L,(34.88±9.07)μg/L,(1.26±0.86)mg/mL,respectively,which were significantly lower than those in the control group[(129.27±28.31)μg/L,(43.27±10.09)μg/L,(2.11±1.03)mg/mL](all P<0.05).There were no other serious adverse reactions in the two groups.ConclusionXiao'er Chiqiaoqingre granule in the treatment of acute upper respiratory tract infection can significantly improve clinical symptoms,improve clinical curative effect,and has good safety and certain clinical value.