甲状腺癌炎性因子的表达水平及临床意义

Expression and Clinical Significance of Inflammatory Factors in Thyroid Carcinoma

目的探讨甲状腺癌炎性因子白介素-6(IL-6)、白介素-17(IL-17)、白介素-35(IL-35)的表达水平及临床意义。方法选取我院2012年1月~2018年1月的38例甲状腺癌患者作为研究组,选取38例健康体检人群作为对照组,采集两组研究对象的空腹血液3ml,离心分离血清,采用酶联免疫吸附法(ELISA)测定两组的血清IL-6、IL-17、IL-35水平,并对血清IL-6、IL-17、IL-35水平与甲状腺癌恶性程度、病理分期进行相关性分析。结果研究组的IL-6和IL-17明显高于对照组,差异有统计学意义(P<0.001);研究组的IL-35水平明显低于对照组,差异有统计学意义(P<0.001);随着甲状腺癌分化程度的降低,血清IL-6、17水平呈上升趋势,血清IL-35水平呈下降趋势,差异有统计学意义<0.01);随着甲状腺癌病理分期的增加,血清IL-6和IL-17水平呈上升趋势,血清IL-35水平呈下降趋势,差异有统计学意义(P<0.01);Spearman相关系数分析血清IL-6和IL-17水平与甲状腺癌恶性程度、病理分期均呈正相关(P<0.001);血清IL-35水平与甲状腺癌恶性程度、病理分期均呈负相关(P<0.001)。结论IL-6和IL-17在甲状腺癌患者血清中高表达,IL-35呈低表达趋势,IL-6、IL-17、IL-35与甲状腺癌发生发展密切相关。

Objective To study the expression and clinical significance of interleukin-6(IL-6),interleukin-17(IL-17) and interleukin-35 (IL-35) in patients with thyroid carcinoma.Methods 38 patients with thyroid cancer between January 2012 and January 2018 were selected as the experimental group and 38 healthy persons as the control group.The serum levels of IL-6, IL-17 and IL-35 were measured by ELISA assay.The correlations between the level of IL-6, IL-17, IL-35 and the tumor differentiation and pathological stage of thyroid carcinoma were analyzed.Results The levels of IL-6 and IL-17 in the experimental group were significantly higher than those in the control group ( P<0.001).The level of IL-35 in the experimental group was significantly lower than that in the control group ( P<0.001).The levels of IL-6 and IL-17 were increased and the level of IL-35 was decreased with the increase of pathological stages of thyroid carcinoma ( P<0.01 ).Spearman analysis showed that serum levels of IL-6 and IL-17 were positively correlated with the tumor malignancy and pathological stage of thyroid carcinoma ( P<0.001 ).The IL-35 level was negatively correlated with the tumor malignancy and pathological stage of thyroid carcinoma (P<0.001).Conclusion The serum levels of IL-6, IL-17 and IL-35 were closely related to the development of thyroid carcinoma.