醒脑静注射液对老年重症肺炎患者血清降钙素原、C反应蛋白、白细胞计数及临床疗效的影响

Effects of Xingnaojing injection on PCT,CRP and WBC in elderly patients with severe pneumonia

目的探讨醒脑静注射液联合盐酸氨溴索对老年重症肺炎患者降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)影响及临床疗效观察。方法选择2013年12月至2015年3月浙江衢化医院收治的老年重症肺炎患者94例,依据随机数字表法分为治疗组47例与对照组47例。对照组采用盐酸氨溴索治疗,治疗组在对照组基础上结合醒脑静注射液治疗。比较两组治疗前后主要症状积分、血气分析指标、PCT、CRP和WBC变化,及治疗疗效。结果治疗组治疗后发热积分(1.03±0.25)分和咳嗽积分(1.12±0.29)分低于对照组发热积分(2.17±0.42)分和咳嗽积分(2.34±0.71)分,且有统计学意义(t=15.989、10.905,P<0.05)。治疗组治疗后PaO2(89.47±8.41)mmHg高于对照组(76.39±5.63)mmHg而PaCO2(48.37±7.19)mmHg低于对照组(63.27±3.48)mmHg,且有统计学意义(t=8.860、12.780,P<0.05)。治疗组治疗后血清PCT(5.41±0.97)ng/L、CRP(48.98±8.97)mg/L和WBC(7.82±1.23)×10^9/L低于对照组PCT(7.98±1.47)ng/L、CRP(76.45±12.54)mg/L和WBC(12.56±1.89)×10^9/L,且有统计学意义(t=10.004、12.214、14.410,P<0.05)。治疗组治疗总有效率(91.49%)高于对照组(72.34%),且有统计学意义(χ^2=5.817,P<0.05)。结论醒脑静注射液联合盐酸氨溴索可降低老年重症肺炎患者血清PCT、CRP和WBC变化,且疗效显著,值得临床推广研究。

Objective To investigate the effect of Xingnaojing injection combined with ambroxol hydrochloride on precalcitonin(PCT),C-reactive protein(CRP)and white blood cell count(WBC)in the elderly patients with severe pneumonia,and to observe the clinical effect.MethodsFrom December 2013 to March 2015,94 cases of severe pneumonia in Zhejiang Quhua Hospital were selected and divided into treatment group and control group according to the random digital table method,with 47 cases in each group.The control group was treated with ambroxol hydrochloride,while the treatment group was treated with Xingnaojing injection on the basis of the control group.The main symptom scores,blood gas analysis indicators,PCT,CRP and WBC changes and therapeutic effects were compared between the two groups before and after treatment.ResultsAfter treatment,the fever score and cough score in the treatment group[(1.03±0.25)points,(1.12±0.29)points]were significanly lower than those in the control group[(2.17±0.42)points,(2.34±0.71)points](t=15.989,10.905,all P<0.05).After treatment,the PaO2 of the treatment group[(89.47±8.41)mmHg]was higher than that of the control group[(76.39±5.63)mmHg],while PaCO2[(48.37±7.19)mmHg]was lower than that in the control group[(63.27±3.48)mmHg],the differences were statistically significant(t=8.860,12.780,all P<0.05).After treatment,the serum levels of PCT,CRP and WBC in the treatment group were(5.41±0.97)ng/L,(48.98±8.97)mg/L,(7.82±1.23)×10^9/L,respectively,which were significanly lower than those in the control group[(7.98±1.47)ng/L,(76.45±12.54)mg/L and(12.56±1.89)×10^9/L](t=10.004,12.214,14.410,all P<0.05).The total effective rate in the treatment group(91.49%)was higher than that in the control group(72.34%),and there was statistically significant difference(χ^2=5.817,P<0.05).ConclusionXingnaojing injection combined with ambroxol can reduce the changes of serum PCT,CRP and WBC in the elderly patients with severe pneumonia,and the curative effect is significant.It is worthy of clinical study.