摘要
目的探究皮内注射谷胱甘肽及氨甲环酸对黄褐斑患者的治疗效果。方法选取2016年7月至2018年5月胜利油田中心医院皮肤科收治的黄褐斑患者96例作为研究对象,采用随机数字表法分成对照组(n=48)和观察组(n=48)。观察两组黄斑颜色和面积、疗效判定(基本治愈、显效、好转、无效)、不良反应(晕针反应、治疗后的复发、肠胃道反应、口腔溃疡和月经量减少)。结果两组治疗后在黄褐斑颜色评分和黄褐斑面积上均有明显的改善(t=9.258、10.774,均P<0.05;t=11.673、12.66,均P<0.05);观察组治疗后黄褐斑颜色评分和面积分别为(1.13±0.91)分、(1.62±1.26)cm^2,显著低于对照组的(0.78±0.62)分、(0.80±0.83)cm^2(t=2.132、3.641,均P<0.05)。就两组的临床疗效比较发现,观察组总有效为91.67%,要显著高于对照组的62.50%(χ^2=11.558,P<0.05)。在治疗期间两组都有出现晕针反应,而在治疗结束后观察组肠胃道反应、口腔溃疡和影响月经上都有发生,但是两组在反应的发生差异无统计学意义(P>0.05)。结论氨甲环酸及谷胱甘肽联合对患者进行皮内注射在减轻患者黄褐斑颜色和减少患者黄褐斑面积具有显著效果,在治疗效果上联合注射组要明显优于常规治疗组,且联合注射组具有一定的安全性。
Objective To explore the effect of intradermal injection of glutathione and tranexamic acid in the treatment of chloasma.MethodsFrom July 2016 to May 2018,96 patients with chloasma admitted to the dermatology department of the Central Hospital of Shengli Oil Field were selected and randomly divided into control group and observation group,with 48 cases in each group.The macular color and area,curative effect(basic cure,obvious effect,improvement,ineffective),adverse reactions(acupuncture reaction,recurrence after treatment,gastrointestinal tract reaction,oral ulcer and menstrual quantity reduction)were observed.ResultsAfter treatment,both two groups showed significant improvement in chloasma color score and chloasma area(t=9.258,10.774,all P<0.05;t=11.673,12.66,all P<0.05).After treatment,the color score and area of chloasma in the observation group were(1.13±0.91)points,(1.62±1.26)cm^2,respectively,which were significantly lower than those in the control group[(0.78±0.62)points,(0.80±0.83)cm^2,t=2.132,3.641,all P<0.05].The total effective rate of the observation group was 91.67%,which was significantly higher than 62.50%of the control group(χ^2=11.558,P<0.05).Both two groups experienced needle sickness during treatment.After treatment,the gastrointestinal tract reaction,oral ulcer and the influence of menstruation occurred in the observation group.However,differences in adverse reaction between the two groups were not significant(all P>0.05).ConclusionThe combination of tranexamic acid and glutathione has significant effect on reducing the color of patients'chloasma and reducing the area of patients'chloasma.In terms of treatment effect,the combined injection group is significantly superior to the conventional treatment group,and the combined injection group has a certain safety.
作者
冯超
颜敏
李娟
张媛
孙莉
Feng Chao;Yan Min;Li Juan;Zhang Yuan;Sun Li(Department of Dermatology,the Central Hospital of Shengli Oil Field,Dongying,Shandong,257000,China)
出处
《中国基层医药》
CAS
2019年第4期473-477,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
氨甲环酸
黄褐斑
谷胱甘肽
黑色素
皮内注射
疗效
不良反应
联合
Tranexamic acid
Chloasma
Glutathione
Melanin
Intradermal injection
Curative effect
Adverse reactions
The joint