老年人衰弱与骨关节炎的研究进展

Research advances in frailty and osteoarthritis in the elderly

骨关节炎是一种慢性退行性关节病,是引起老年人关节疼痛和失能常见的原因之一。衰弱是一种随增龄而导致多种生理功能出现衰退的病理生理状态,可引起自体稳态平衡能力下降从而导致失能、疾病发生甚至最终导致死亡。衰弱前状态是衰弱的早期阶段,与衰弱后期发展密切相关。多项临床研究已采用不同的诊断标准阐释了骨关节炎和衰弱在疾病发展过程中两者的相互关系,识别衰弱前状态和衰弱对老年骨关节炎患者干预措施的选择及阻止或延缓失能的发生是必要的;衰弱能够明显预测死亡率,尤其是伴有骨关节炎者。

Osteoarthritis(OA)is a chronic degenerative joint disease and one of the most common causes of pain and disability in the elderly.Frailty is a physiological state characterized by the deregulation of multiple physiologic systems in an aging organism, leading to the loss of homeostatic capacity that exposes the elderly to disability, disease, and eventual death.Prefrailty occurs at an earlier stage of the frailty spectrum and is closely associated with later development of frailty.A large number of studies, using various diagnostic criteria, have addressed the interrelationship between OA and frailty during their disease development processes.Identifying prefrailty and frailty is necessary for the choice of intervention measures and the prevention or delay of disability occurrence in elderly OA patients.Frailty can be considered as a new prognostic factor for mortality, especially in individuals with OA.