用血栓通联合低分子肝素钠对行老年髋部骨折手术患者进行抗凝治疗的效果研究

Effect of Xueshuantong Injection and low-molecular-weight heparin for anticoagulation of senile hip fracture patients received operation

目的:分析用血栓通联合低分子肝素钠对接受手术治疗的老年髋部骨折患者进行抗凝治疗的效果。方法:选取2014年12月至2017年12月期间在成都市龙泉驿区第一人民医院接受诊治的80例老年髋部骨折患者作为研究对象。采用随机数表法将其分为对照组与观察组。对两组患者均进行手术治疗。在术后,对其均进行康复训练指导。在此基础上,为对照组患者单用低分子肝素钠进行抗凝治疗,为观察组患者联用血栓通和低分子肝素钠进行抗凝治疗。然后对比两组患者术后肺栓塞、下肢深静脉血栓的发生情况和各项凝血指标的变化情况。结果:观察组患者术后肺栓塞的发生率(0%)、下肢深静脉血栓的发生率(10%)均低于对照组患者术后肺栓塞的发生率(20%)、下肢深静脉血栓的发生率(30%),P <0.05。治疗后,两组患者HGB的水平、PLT计数均较治疗前明显降低,其PT、APTT均较治疗前明显延长,P <0.05。两组患者治疗后HGB的水平、PLT计数、PT、APTT相比,P>0.05。结论:用血栓通联合低分子肝素钠对接受手术治疗的老年髋部骨折患者进行抗凝治疗能够改善其各项凝血指标,降低其术后下肢静脉血栓、肺栓塞的发生率。

objective: to analyze the anticoagulant effect of xueshuantong combined with low molecular weight heparin sodium in the treatment of elderly patients with hip fracture undergoing surgery. Methods: 80 elderly patients with hip fracture who received treatment in the first people’s hospital of longquanyi district, chengdu from December 2014 to December 2017 were selected as the research objects. Random number table method was used to divide them into control group and observation group. Both groups were treated with surgery. After the operation, all the patients received rehabilitation training instruction. On this basis, the patients in the control group were treated with low molecular heparin sodium alone for anticoagulation therapy, and the patients in the observation group were treated with xueshuantong and low molecular heparin sodium for anticoagulation therapy. Then the incidence of postoperative pulmonary embolism, deep venous thrombosis in lower limbs and the changes of coagulation indexes were compared between the two groups. Results: the incidence of postoperative pulmonary embolism(0%) and lower extremity deep vein thrombosis(10%) in the observation group was lower than that in the control group(20%) and lower extremity deep vein thrombosis(30%), P < 0.05. After treatment, HGB level and PLT count in both groups were significantly lower than before treatment, and PT and APTT in both groups were significantly longer than before treatment, P < 0.05.Compared with HGB level, PLT count, PT and APTT, P > was 0.05 in the two groups after treatment. Conclusion: anticoagulant therapy with xueshuantong combined with low molecular heparin sodium can improve the blood coagulation indexes and reduce the incidence of postoperative venous thrombosis and pulmonary embolism in elderly patients with hip fracture.