肠屏障与肠源性内毒素血症

Intestinal barrier and intestinal endotoxemia

机体在感染、外伤或应激状态下会引起肠道功能障碍,肠黏膜屏障损伤是危重患者常见的病理生理过程,肠道是严重感染、组织缺氧缺血时受影响最早和最严重的器官之一,肠道损伤后导致大量菌群易位,从而引起肠源性感染、肠源性内毒素血症及肠源性脓毒症。胃肠屏障功能障碍与危重患者的预后密切相关。本文具体论述正常肠道屏障功能,胃肠功能障碍,外伤、应激对肠屏障功能的影响,及菌群和内毒素易位对机体的影响和预防与治疗。

Intestinal dysfunction can be induced under infection,trauma or stress.The intestinal mucosal barrier injury is a common pathophysiological process in critically ill patients.The bowel is one of the earliest and most severely affected organ under severe infection and tissue hypoxia-ischemia.Intestinal damage leads to a large number of bacterial flora shift,resulting in intestinal infection,intestinal endotoxemia and intestinal sepsis.In recent years,gastrointestinal barrier function has attracted people's attention,which is closely related to the prognosis of critically ill patients.This article described the normal intestinal barrier function,the effects of trauma and stress on intestinal barrier function,bacterial group migration,and the effects of endotoxin translocation on the body and its prevention and treatment.