自噬的分子机制与慢性髓细胞白血病的关系

Relationship between molecular mechanism of autophagy and chronic myeloid leukemia

自噬是一种普遍存在于细胞的生理现象,与细胞的生长、增殖、分化、凋亡、癌变均有密切的关系。慢性髓细胞白血病(CML)是骨髓造血干细胞克隆性增殖形成的恶性肿瘤,自噬可能在其发生、治疗、耐药等方面发挥着重要作用。因此,研究自噬的分子机制及其与CML的关系,为针对自噬开发治疗CML的新药提供一定的理论指导。笔者就自噬的分子机制及自噬与CML的关系进行综述。

Autophagy is a common physiogical phenomenon in cells, which is closely related to cell growth, differentiation, apoptosis and carcinogenesis. Chronic myeloid leukemia (CML) is a malignant tumor formed by clonal proliferation of bone marrow hematopoietic stem cells. Autophagy may play an important role in occurrence, treatment and drug resistance of CML. Therefore, the study of the molecular mechanism of autophagy and its relationship with CML may provide a theoretical guide for the development of new drugs targeting autophagy in the treatment of CML. This paper reviews the molecular mechanism of autophagy and the relationship between autophagy and CML.