川崎病诊断中的生物标志物

Biomarkers for the diagnosis of Kawasaki disease

川崎病是一种急性、自限性的全身血管炎综合征,好发于5岁以下的婴幼儿,是儿童后天性心脏病最主要的原因。川崎病相关的冠状动脉扩张、动脉瘤可致心肌梗死或死亡,严重危害婴幼儿的健康,所以早期诊断尤为重要。目前其诊断主要依靠临床症状,缺乏特异性的诊断性实验室检测手段,对于不完全性川崎病可因漏诊或误诊而延误治疗。近年来,许多研究致力于探索对早期川崎病诊断具有较好特异性和敏感性的生物标志物,现就相关研究的进展综述如下。

Kawasaki disease (KD) is an acute, self-limiting systemic vascular syndrome that mainly occurs in infants and children under the age of five years, and is the leading cause of acquired heart disease in children.Kawasaki disease can lead to coronary dilatation, coronary aneurysm, which can cause myocardial infarction or death, seriously harm the health of infants and children, and thus early diagnosis is critically important.Till now the diagnosis is based mainly on the clinical symptoms for the lack of diagnostic laboratory tests.In recent years, many studies have been carried out to explore the potential biomarkers with high sensitivity and specificity in the early diagnosis of KD.The article reviews the progress of the related studies.