儿茶素治疗儿童慢性心力衰竭的作用机制研究进展

Catechin for the pharmacotherapy of chronic heart failure

心力衰竭是由于各种功能性或器质性病变引起心脏前、后负荷增加,心脏泵血功能进行性下降,致体(肺)循环淤血及组织灌注不足的一组临床症候群,是心血管疾病发展的终末阶段。儿童慢性心力衰竭可由多种先天性及后天性心脏病引起,目前临床治疗以对症治疗为主,但其并不能有效改善慢性心力衰竭患儿预后及生活质量。现代研究表明儿茶素具有多种药理作用,对心血管具有保护作用,但其作用机制尚未完全明确。该文将对儿茶素在儿童慢性心力衰竭的临床应用及作用机制进行综述。

Heart failure is an end stage of the process of cardiovascular diseases.It is a condition of the heavy preload and afterload of heart, where it was associated with a progressive dysfunction of cardiac ejection.It can cause the systemic (pulmonary) congestion and the perfusion deficiency.For chronic heart failure in children, it could be resulted from some congenital and obtained heart diseases.The clinical pharmacotherapy strategy is mainly focused on the symptoms, yet which could not improve the prognosis and quality of life.Current studies have demonstrated catechins with a variety of physiological functions that may be responsible for clinically beneficial effects.It has been identified as a protective role in cardiovascular diseases with an unclear mechanism.Hence, this paper reviewed the mechanism of catechins in chronic heart failure in children.