免疫受体NKG2D及其配体介导的细胞免疫与疾病的关系

Immunoreceptor NKG2D and its ligand-mediated cellular immunity and its relationship with diseases

自然杀伤细胞(natural killer,NK)在宿主防御中起重要作用,NKG2D以同源二聚体形式表达于NK细胞表面,是一种重要的淋巴细胞活化性受体。NKG2D配体在正常细胞表面阴性表达或较低水平表达,但当细胞处于氧化应激、恶性病变、自身免疫或炎性病变时,这些配体将在细胞表面诱导性表达。NKG2D受体及其配体介导的细胞免疫应答对肿瘤细胞的免疫监视起着重要作用,同时与某些自身免疫性疾病也有着密切联系。

Natural killer (NK) cells play an important role in host defense.NKG2D is expressed as a homodimer on the surface of NK cells and is an important lymphocyte activating receptor.NKG2D ligands are negatively or poorly expressed on the surface of normal cells, but when the cells are in a state of oxidative stress, malignant transformation, autoimmune or inflammatory stimulation, these ligands will be induced on the cell surface.The NKG2D receptor and its ligand-mediated cellular immune response play an important role in immune surveillance of tumor cells, and at the same time it is also closely related to certain autoimmune diseases.