老年人阻塞性睡眠呼吸暂停与肌少症的相关性研究

Relationship between obstructive sleep apnea and sarcopenia in the elderly

目的探讨老年人阻塞性睡眠呼吸暂停(OSA)与肌少症的相关性。方法回顾性分析,连续入选2015年1月至2017年12月就诊于天津医科大学总医院保健医疗部320例老年患者进行对照研究,年龄65~85岁,其中肌少症组110例和对照组210例。收集患者病史和OSA和肌少症的诊断资料。应用多因素Logistic回归法评价OSA与肌少症的相关性。结果肌少症组平均年龄高于对照组(P<0.001).与对照组比较,肌少症组男性比例大(P=0.015),肌少症组肥胖、2型糖尿病、痴呆或OSA比例高(P=0.038,P=0.021,P=0.032.P=0.018).年龄》74.3岁(OR=1.63,95%CI:1.03~2.61)、男性(OR=1.79,95%CI:1.13~2.85)、肥胖(OR=1.70,95%CI: 1.01~2.90),2型糖尿病(OR=1.91,95%CI:1.11~3.29)、痴呆(OR=1.92,95%CI:1.05~3.49)和OSA(OR=2.24,95%CI:1.15~4.40)与肌少症的发生相关,OSA患者比非OSA患者更易患肌少症。结论在老年人群中,OSA与肌少症发病相关。

Objective To explore the relationship between obstructive sleep apnea syndrome (OSA)and sarcopenia in elderly.Methods In the retrospective analysis? totally 320 elderly patients aged 65-85 years were successively enrolled from Department of Geriatrics? General Hospital of Tianjin Medical University from January 2015 to December 2017 ,and divided into the sarcopenia group (n= 110) and the control group (n=210).Clinical and diagnostic data of OSA and sarcopenia were collected.The correlation between OSA and sarcopenia was evaluated by using multivariate Logistic regression.Results The average age was higher in the sarcopenia group than in the control group (P 0.001 ).Compared with the control group, the sarcopenia group had higher proportions of patients with male (P=0.015), with obesity, type 2 diabetes, dementia or OSA (P=0.005,0.021,0.032 and 0.018, respectively).Multivariate Logistic regression showed that risk factors for sarcopenia were age$74.3 years (OR=1.63,95%CI: 1.03?2.61), male COR=1.79,95%CI: 1.1~2.85), obesity (OR=1.70,95%CI:1.01~2.90), type 2 diabetes (OR=1.91, 95 % CI: 1.11~3.29), dementia (OR=1.92, 95% CI: 1.05 ~3.49) and OSA (OR=2.24,95 %CI:1.15~4.40)(P<0.001, 0.015,0.038, 0.021, 0.032 and 0.018, respectively).OSA patients is more prone to sarcopenia than patients without OSA (OR=2.24,95% CI:1.15 ~4.40).Conclusions OSA is correlated with sarcopenia in the elderly.