他汀类药物的多效性在老年患者中应用研究进展

Research advances in pleiotropic effects of statins in elderly patients

他汀类药物是羟甲基戊二酰基-CoA(HMG-CoA)还原酶抑制剂的统称,通过抑制甾醇生物合成途径中的关键步骤,发挥强有力的降胆固醇作用。目前全球有近2亿人使用他汀类药物,随着临床研究的深入,其多效性被逐渐发现,特别是在老年发病率较高的循环系统、神经系统、消化系统等疾病的预防和治疗中发挥越来越重要的作用。在警惕他汀类药物的一些不良反应的同时,要重视他汀类药物的多效性在老年患者中的应用情况。

Statins are collectively referred to as hydroxymethylglutaryl-CoA(HMG-CoA)reductase inhibitors.They exert powerful cholesterol-lowering effects by inhibiting key steps in the sterol biosynthetic pathway.At present, nearly 200 million people worldwide use statins.As clinical research progresses, the pleiotropic effects of statins are gradually discovered, especially those in the prevention and treatment of diseases of the circulatory system, nervous system and digestive system with high incidences in the elderly.We should to be alert to the adverse effects of statins and pay attention to the pleiotropic effects of statins in the elderly at the same time.