3型天然淋巴细胞在肠道屏障中的作用

Role of group 3 innate lymphoid cells in intestinal barrier

肠道屏障是机体抵御病原体入侵的重要防线,对维持机体肠道局部及全身稳态有重要意义。重症全身性疾病可导致肠道屏障受损,肠道屏障损伤除可引发多种胃肠道疾病外,还可恶化重症全身性患者的疾病进程。天然淋巴细胞(ILCs)是一类新发现的具有适应性免疫细胞特征的固有免疫细胞,其中3型天然淋巴细胞(ILC3)主要分布于肠道黏膜组织,在维护肠道屏障功能中起着重要作用。本文通过综述ILC3的起源、分类及功能,重点聚焦ILC3在维护肠道屏障功能中的作用,为病理状态下维持肠道屏障功能提供新的理论基础。

Intestinal barrier act as the crucial defender against pathogen invasion, and is indispensable in maintaining tissue homeostasis both locally and systemically. Severe disease can lead to impaired intestinal barrier. In addition to cause a variety of gastrointestinal diseases, intestinal barrier damage can also worsen the disease progression in critically ill patients. Innate lymphoid cells (ILCs) is a group of newly defined innate immune cells which have some characteristics as adaptive immune cells. Group 3 innate lymphoid cells (ILC3), which mainly reside at gut associate mucosal tissue, have been reported to play a critical role in maintaining intestinal barrier function. After a brief introduction about its origination and classification, we will focus on function of ILC3 physiologically and pathologically, and provide a new theoretical basis for maintaining intestinal barrier function under pathological conditions in this review.