盐酸替罗非班对介入栓塞颅内动脉瘤栓塞过程中急性血栓形成的安全性及有效性研究

Application of Tirofiban for the Treatment of Acute Thromboembolism During Embolization Therapy for Intracranial Aneurysms

目的探讨在颅内动脉瘤栓塞过程中急性血栓事件形成,使用盐酸替罗非班处理的安全性及有效性.方法2010年1月—2017年12月进行介入栓塞颅内动脉瘤患者中,有17例发生了急性血栓事件,术中给予盐酸替罗非班动脉内接触性溶栓联合静脉低剂量持续给药,对患者临床资料、手术过程及预后情况进行回顾性分析.结果有17例患者在动脉瘤介入栓塞过程中发生急性血栓事件.17例患者中12例为破裂动脉瘤,5例为未破裂动脉瘤,给予盐酸替罗非班后急性血栓形成的血管均有再通,顺利完成了动脉瘤的栓塞治疗,术后CT检查未见有颅内新鲜出血.术后CT复查2例有脑梗塞表现.结论颅内动脉瘤栓塞术中急性血栓形成需紧急处理,术中应用盐酸替罗非班是安全有效的.

Objective To evaluate the safety and efficacy of tirofiban in managing acute thromboembolism during embolization therapy for intracranial aneurysms.Methods A total of 17 patients were enrolled in this study from January 2010 to December 2017.Acute thromboembolism occurred in these patients during embolization therapy for intracranial aneurysms.Tirofiban was infused through artery and then continuous intravenous administration.The clinical results were analyzed.Results Angiography performed during the procedure showed that in all the 17 patients of the study group the diseased vessels were reopened,and no signs of newly-developed intracranial bleeding were detected and cerebral infarction occurred in 2 patients on CT scans.Conclusion Tirofiban is a safe and effective treatment for acute thromboembolism occurring during embolization therapy for intracranial aneurysms.