老年晚期非小细胞肺癌患者的治疗

Therapy for elderly patients with advanced non-small cell lung cancer

化疗通常被推荐用于ⅢB/Ⅳ期非小细胞肺癌(NSCLC)的治疗,老年晚期NSCLC患者的治疗方案主要为单药化疗以及以铂类为基础的联合化疗。但是老年患者由于年龄相关的一些疾病导致化疗耐受性差,因此疗效相对于年轻患者差。靶向治疗及免疫治疗成为新的研究方向。根据老年患者特点(老年状态评分系统)选择合适的方案十分重要。

Chemotherapy is recommended for stage Ⅲ B/ Ⅳ non-small cell lung cancer (NSCLC) treatment.The treatments for elderly patients with advanced NSCLC are mainly single-agent chemotherapy and platinum-based combination chemotherapy.However,elderly patients tolerate chemotherapy poorly because of agerelated comorbidities.Therefore,the curative effect of elderly patients is relatively poorer as compared to their younger counterparts.Targeted therapy and immune therapy have become new research directions.It is important to select an appropriate program for elderly patients according to geriatric assessments.