间充质干细胞外泌体:眼部给药的可选择载体

Mesenchymal stem cells derived exosomes:an alternative drug carrier for eye disease

间充质干细胞(MSC)广泛应用于包括眼科在内的多种疾病治疗研究。近年研究表明,MSC外泌体具有与MSC类似的生物学功能,可替代MSC用于多种疾病治疗。外泌体是一类纳米级的具有脂质双分子层结构的小囊泡,可以介导细胞与细胞之间信号传导,发挥多种生物学功能。由于外泌体特殊的生物学结构,可穿越生物屏障,因而有望作为药物载体实现靶向运输,成为眼部给药的可选择载体。

Mesenchymal stem cells (MSCs) are considered as an ideal treatment for multiple diseases including ocular disease. Recent studies have demonstrated that MSCs-derived exosomes have similar functions with MSCs. Exosomes are nanovesicles surrounded by a phospholipid layer that shuttle active cargo between different cells. They are capable of passing the biological barrier and have potentials to be utilized as natural carrier for the ocular drug delivery.