抗精神病药物联合生物反馈治疗对首发精神分裂症患者疗效及生活质量的影响

Effects of antipsychotic drugs combined with biofeedback ther-apy on efficacy and quality of life in patients with first-episode schizophrenia

目的探讨抗精神病药物联合生物反馈治疗对首发精神分裂症患者疗效及生活质量的影响.方法将80例首发精神分裂症患者按随机数字表法分为研究组和对照组,每组40例,均予以口服抗精神病药(利培酮)治疗和常规护理干预,研究组在上述治疗基础上联合生物反馈治疗,观察4周.治疗前后采用阳性与阴性症状量表评定精神症状,汉密顿焦虑量表评定焦虑症状,精神分裂症病人生活质量量表评定生活质量.结果干预前两组各量表评分比较差异均无统计学意义(P>0.05);干预后研究组各量表评分均较干预前显著下降(P<0.01),且均显著低于对照组(P<0.05或0.01),对照组仅汉密顿焦虑量表总分、精神分裂症病人生活质量量表症状和副作用分量表评分较干预前显著下降(P<0.05或0.01).结论抗精神病药物联合生物反馈治疗首发精神分裂症患者具有协同增效作用,能显著提高临床疗效,改善焦虑症状及生活质量,显著优于单纯应用抗精神病药物治疗.

Objective To investigate the effects of antipsychotic drugs combined with biofeedback therapy on efficacy and quality of life in patients with first-episode schizophrenia.Methods 80 patients with firstepisode schizophrenia were randomly divided into the study group and the control group,40 cases in each group.They were all given oral antipsychotics(risperidone)treatment and routine nursing intervention,the study group was given biofeedback therapy based on the above treatment for 4 weeks.Before and after treatment,the PANSS was used to assess mental symptoms,the HAMA was used to assess anxiety symptoms,and the SQLS was used to assess quality of life.Results There was no significant difference in the scores between the two groups before the intervention(P>0.05).After the intervention,the scores of the scales of the study group were significantly lower than those before the intervention(P<0.01),and both were significantly lower than those of the control group(P<0.05 or 0.01).In the control group,only the total score of the HAMA,the SQLS and side effect scores were significantly lower than those before the intervention(P<0.05 or 0.01).Conclusion Antipsychotic drugs combined with biofeedback therapy for patients with first-episode schizophrenia have synergistic effects,can significantly improve clinical efficacy,improve anxiety symptoms and quality of life,significantly better than the simple application of antipsychotic drugs.