茶碱缓释片联合布地奈德福莫特罗治疗慢性阻塞性肺疾病临床研究

bined with budesonide formoterol in the treatment of chronic obstructive pulmonary disease

目的探讨茶碱缓释片联合布地奈德福莫特罗吸入治疗慢性阻塞性肺疾病患者的临床疗效.方法将150例慢性阻塞性肺疾病患者按随机数字表法分为观察组与对照组,每组75例,对照组采用常规治疗+布地奈德福莫特罗吸入治疗,观察组在对照组治疗的基础上给予口服茶碱缓释片治疗,观察2个月.治疗前后检测两组肺活量、呼气容积、用力肺活量等肺功能指标及血清肿瘤坏死因子-α、超敏C反应蛋白、白介素-6水平变化;比较两组临床疗效.结果治疗2个月后观察组总有效率(89.3%)显著高于对照组(76.0%)(P<0.05);疗程结束后观察组肺活量、呼气容积、用力肺活量显著高于对照组(P<0.05或0.01),血清肿瘤坏死因子-α、超敏C反应蛋白、白介素-6因子水平显著低于对照组(P<0.01).结论茶碱缓释片联合布地奈德福莫特罗治疗慢性阻塞性肺疾病患者疗效确切,且能显著改善患者的肺功能,降低炎性反应,具有一定的临床价值.

Objective To investigate the clinical effect of theophylline sustained-release tablets combined with budesonide formoterol in the treatment of chronic obstructive pulmonary disease.Methods 150 patients with chronic obstructive pulmonary disease were randomly divided into observation group and control group,75 cases in each group.The control group was treated with conventional treatment+budesonide formoterol inhalation.The observation group was treated with oral theophylline sustained-release tablets on the basis of the control group for 2 months.Before and after treatment,lung function indexes such as lung capacity,expiratory volume and forced vital capacity were measured,and changes in serum levels of tumor necrosis factor-a,high-sensitivity C-reactive protein and interleukin-6 were measured.The clinical efficacy of the two groups was compared.Results After 2 months of treatment,the total effective rate of the observation group(89.3%)was significantly higher than that of the control group(76.0%)(P<0.05);at the end of the treatment period,the lung capacity,expiratory volume,and forced vital capacity of the observation group were significantly higher than those of the control group(P<0.05 or 0.01).The levels of serum tumor necrosis factor-a,high-sensitivity C-reactive protein and interleukin-6 were significantly lower than those in the control group(P<0.01).Conclusion theophylline sustainedrelease tablets combined with budesonide formoterol are effective in the treatment of patients with chronic obstructive pulmonary disease,and can significantly improve the lung function and reduce the inflammatory response,which has certain clinical value.