复方甘草酸苷联合窄谱中波紫外线治疗中老年寻常型银屑病

Study on compound glycyrrhizin combined with Narrow-band UVB in the treatment of middle-aged psoriasis vulgaris

目的探讨复方甘草酸苷片联合窄谱中波紫外线照射治疗中老年寻常型银屑病患者的临床疗效及安全性.方法将96例中老年寻常型银屑病患者按随机数字表法分为观察组(n=48)与对照组(n=48).观察组予以复方甘草酸苷片联合窄谱中波紫外线照射治疗,对照组仅采用窄谱中波紫外线照射治疗,观察8周.治疗前后采用银屑病皮损面积与严重程度指数评分结果评定临床疗效,治疗过程中随时记录出现的不良反应,治疗后随访6个月统计复发率.结果治疗8周末观察组总有效率(87.50%)显著高于对照组(70.83%)(P<0.05),治疗4周、8周末银屑病皮损面积与严重程度指数评分及随访6个月复发率均显著低于对照组(P<0.05或0.01),不良反应发生率(10.42%)与对照组(16.67%)比较差异无统计学意义(P>0.05).结论复方甘草酸苷片联合窄谱中波紫外线治疗中老年寻常型银屑病患者具有协同增效作用,临床疗效显著,能降低复发率,且不增加不良反应,安全性高.

Objective To investigate the clinical effect and safety of compound glycyrrhizin combined with Narrow-band UVB in the treatment of middle-aged psoriasis vulgaris.Methods 96 cases of psoriasis vulgaris were selected and divided into the observation group(n=48)and the control group(n=48)accord-ing to the random number table method.The observation group was treated with compound glycyrrhizin tablets combined with Narrow-band UVB.The control group was treated with Narrow-band UVB alone for 8 weeks.The clinical efficacy was assessed by PASI score before and after treatment,and the adverse reactions were recorded at any time during the treatment and the recurrence rate was followed up for 6 months after treatment.Results After 8 weeks of treatment,the total effective rate of the observation group was 87.50%,which was higher than that of the control group(70.83%)(P<0.05).After 4 weeks and 8 weeks of treatment,the PASI score and the recurrence rate after 6 months'follow-up were significantly lower than those of the control group(P<0.05 or 0.01).The incidence of adverse reactions(10.42%)was not significantly different from that of the control group(16.67%)(P>0.05).Conclusion Compound glycyrrhizin tablets combined with Narrow-band UVB in the treatment of middle-aged psoriasis vulgaris have synergistic effects,the clinical efficacy is significant,which can reduce the recurrence rate without increasing adverse reactions and has high safety.