慢性乙型肝炎患者血清甲状腺激素水平与乙肝表面抗原的相关性

Correlation between serum thyroid hormones levels and hepatitis B surface antigen in patients with chronic hepatitis B

目的探究慢性乙型肝炎患者血清甲状腺激素水平与乙肝表面抗原的相关性.方法将120例慢性乙型肝炎患者按照血清中乙肝表面抗原检测结果分为低水平组、中等水平组、高水平组,每组40例,选取同期进行健康体检的健康志愿者40名设为健康组.检测各组甲状腺激素水平,指标包括促甲状腺激素、游离三碘甲状腺原氨酸、游离甲状腺素、总三碘甲状腺原氨酸、总甲状腺素.结果患者组促甲状腺激素、总三碘甲状腺原氨酸、总甲状腺素水平显著低于健康组(P<0.01);患者组随着乙肝表面抗原表达增加促甲状腺激素、总三碘甲状腺原氨酸、总甲状腺素水平逐渐降低(P<0.01);患者组促甲状腺激素、总三碘甲状腺原氨酸、总甲状腺素水平与乙肝表面抗原表达呈显著负相关(P<0.05).结论慢性乙型肝炎患者促甲状腺激素、总三碘甲状腺原氨酸、总甲状腺素水平与乙肝表面抗原表达呈显著负相关,检测患者甲状腺激素水平的变化,对指导临床治疗具有重要意义.

Objective To explore the correlation between serum thyroid hormones levels and hepatitis B surface antigen in patients with chronic hepatitis B.Methods 120 cases of patients with chronic hepatitisB were divided into low-level group,middle-level group and high-level group according to the test results of serum hepatitis B surface antigen,with 40 cases in each group.Another 40 healthy volunteers who were selected for healthy physical examination at the same time were set as healthy group.The levels of thyroid hormones were measured in each group,including thyroid stimulating hormone,free triodothyronine,free thyroxine,total triiodothyronine,and total thyroxine.Results The levels of thyroid stimulating hormone,total triiodothyronine and total thyroxine in the patient group were significantly lower than those in healthy group(P<0.01).The levels of thyroid stimulating hormone,total triiodothyronine and total thyroxine were decreased gradually in patient group with the increase of expression of hepatitis B surface antigen(P<0.01).The levels of thyroid stimulating hormone,total triiodothyronine and total thyroxine were significantly negatively correlated with hepatitis B surface antigen expression(P<0.05).Conclusions The levels of thyroid stimulating hormone,total triiodothyronine and total thyroxine in patients with chronic hepatitis B are significantly negatively correlated with the expression of hepatitis B surface antigen.The detection of thyroid hormone levels in patients with chronic hepatitis B is of great significance for guiding clinical treatment.