Levels of bisphenols in patients with chronic kidney disease and their correlation with renal function

Objective To observe the levels of four bisphenols(bisphenol A,B,S and F)and their correlation with renal function in chronic kidney disease(CKD)patients.Methods Patients with CKD were identified according to Kidney Disease:Improving Global Outcomes(KDIGO)criteria.Sixty-three CKD patients and eleven healthy controls were enrolled.CKD patients were further classified as mild renal injury group(CKD stage 1 and 2,n=30),moderate renal injury group(CKD stage 3,n=19)and severe renal injury group(CKD stage 4 and 5,n=14).The levels of four bisphenols in serum were determined by high performance liquid chromatography(HPLC).The correlation between concentrations of four bisphenols and estimated glomerular filtration rate(eGFR)was assessed by Spearman's rank correlation analysis.The associations of four bisphenols with coronary heart disease,diabetes and hypertension in CKD patients were estimated by binary multivariate logistic regression.Results(1)Four bisphenols were not detected in serum of the healthy control.In the mild renal injury group the bisphenol A and bisphenol S were not detected,and patients had 5.24(5.24,9.38)μg/L bisphenol B and 0.74(0.74,0.74)μg/L bisphenol F.In the moderate renal injury group bisphenol S was not detected,and the patients had 2.79(1.01,4.53)μg/L bisphenol A,5.24(5.24,5.24)μg/L bisphenol B and 0.74(0.74,0.74)μg/L bisphenol F.In the severe renal injury group the patients had 14.30(7.97,18.17)μg/L bisphenol A,0 μg/L bisphenol B,23.73(23.73,136.59)μg/L bisphenol S and 0.74(0.74,1.42)μg/L bisphenol F.The levels of bisphenol A and bisphenol S in the severe renal injury group were higher than those in the healthy control group,the mild renal injury group and the moderate renal injury group(all P<0.05).Bisphenol B and bisphenol F were not statistically different among the four groups.(2)Bisphenol A and bisphenol S were negatively correlated with eGFR(r=-0.779,P<0.001;r=-0.546,P<0.001).(3)Among CKD patients,bisphenol A was correlated with diabetes(OR=4.951,95% CI 1.603-15.294,P=0.005),and bis-phenol S was correlated with hypertension(OR=4.466,95% CI 1.575-12.666,P=0.005).Conclusion CKD patients have a variety of bisphenol compounds,especially bisphenol A and bisphenol S.Bisphenol A and bisphenol S have high levels,and their exposures are correlated with renal function.