摘要
Objective To investigate the incidence and clinical features to probe the risk factors of hemorrhagic cystitis(HC)in children and adolescents with hematological diseases post haplohematopoietic stem cell transplantation(haplo-HSCT).Methods Medical records of 62 children and 27 adolescents with hematological diseases treated with haplo-HSCT between 2015 and 2016 were analyzed.Results Of 89 cases(56 boys and 33 girls),44 patients were diagnosed with ALL,33 AML,3 AHL and 9 MDS.HC occurred in 32 of the 89 patients with an incidence of 36%,including 6 with grade Ⅰ,16 with grade Ⅱ,8 with grade Ⅲ,2 with grade Ⅳ HC,respectively.The median time of HC onset was 25 days(range 2-55 days)after haplo-HSCT with the median duration as 19 days(range 3-95 days),and all of them were cured.The incidence of HC was lower in the group of children than that in the group of adolescents(27.4% vs 55.6%,X^2=6.466,P<0.05),and the incidence of HC was higher in the group of patients who were≥5 years old than that in the group of patients who were<5 years old(0 vs 34%,X^2=4.043,P<0.05).Conclusion HC is one of the common complications in children and adolescents with hematological diseases post haplo-HSCT,and older age is associated with increased mortality.
