Clinical analysis of hemorrhagic cystitis in children and adolescents with hematological diseases post haplo-hematopoietic stem cell transplantation

Objective To investigate the incidence and clinical features to probe the risk factors of hemorrhagic cystitis(HC)in children and adolescents with hematological diseases post haplohematopoietic stem cell transplantation(haplo-HSCT).Methods Medical records of 62 children and 27 adolescents with hematological diseases treated with haplo-HSCT between 2015 and 2016 were analyzed.Results Of 89 cases(56 boys and 33 girls),44 patients were diagnosed with ALL,33 AML,3 AHL and 9 MDS.HC occurred in 32 of the 89 patients with an incidence of 36%,including 6 with grade Ⅰ,16 with grade Ⅱ,8 with grade Ⅲ,2 with grade Ⅳ HC,respectively.The median time of HC onset was 25 days(range 2-55 days)after haplo-HSCT with the median duration as 19 days(range 3-95 days),and all of them were cured.The incidence of HC was lower in the group of children than that in the group of adolescents(27.4% vs 55.6%,X^2=6.466,P<0.05),and the incidence of HC was higher in the group of patients who were≥5 years old than that in the group of patients who were<5 years old(0 vs 34%,X^2=4.043,P<0.05).Conclusion HC is one of the common complications in children and adolescents with hematological diseases post haplo-HSCT,and older age is associated with increased mortality.