机械通气联合氧气驱动雾化吸入治疗重症哮喘合并呼吸衰竭的临床研究

Clinical study of mechanical ventilation combined with oxygen atomization inhalation in the treatment of severe asthma complicated with respiratory failure

目的探讨机械通气联合氧气驱动雾化吸入治疗重症哮喘合并呼吸衰竭的临床效果。方法回顾性分析2013年1月至2017年12月应急总医院收治的重症哮喘合并呼吸衰竭患者92例,根据治疗方法不同将患者分为对照组和研究组,对照组应用有创机械通气治疗,研究组应用有创机械通气并联合雾化治疗。比较两组患者治疗后的症状改善情况,各项生命体征、炎性因子水平、肺功能指标变化。结果研究组各项生命体征变化优于对照组(P<0.05);研究组症状改善情况优于对照组(P<0.05);研究组炎性因子水平低于对照组(P<0.05);研究组肺功能指标优于对照组(P<0.05)。结论治疗重症哮喘合并呼吸衰竭患者的过程中,氧气驱动雾化吸入联合机械通气辅助治疗的效果较好。

Objective To explore the clinical effect of oxygen driven atomization inhalation combined with mechanical ventilation to treat severe asthma combined with respiratory failure.Methods Ninty-two cases of patients with severe asthma were selected in our hospital's from January 2013 December 2017,which were randomly divided into two groups,control group applied ventilator therapy.The study group was treated with respiratory and combined atomization therapy.The changes of vital signs,symptoms,inflammatory factors and pulmonary function were compared between the two groups after treatment.Results The vital signs of the group were better than the control group(P<0.05).The symptom improvement of the group was better than that of the control group(P<0.05).The level of inflammatory factors in the group was lower than that in the control group(P<0.05).The lung function index of the group was superior to the control group(P<0.05).The surgical indexes of the group were superior to the control group(P<0.05).Conclusions In the treatment of patients with severe asthma combined with respiratory failure,the effect of air driven atomization inhalation combined with mechanical ventilation is better,and it should be promoted and used.