自噬对肿瘤放射治疗疗效的影响

Influence of autophagy on the efficacy of radiotherapy

自噬是一种重要的分解代谢过程,细胞消化和再循环自身的细胞质内容物以维持细胞稳态。自噬可以通过各种信号通路在肿瘤的发生发展中起到促进和抑制的双重作用。作为研究热点,自噬正被学者们从各个方面进行探索。然而,目前缺乏关于自噬与放疗关系的系统性总结。因此,笔者将从自噬对不同类型肿瘤放射敏感性和对放疗疗效的影响及自噬修饰用于改善肿瘤放疗疗效和预后的未来发展作一综述。

Autophagy is a vital catabolic process in which cells maintain their homeostasis by digesting and circulating their own cytoplasmic contents.Autophagy could promote and inhibit the development of cancer through various signal pathways.Autophagy has been explored from different aspects.However,few summaries systematically illuminate the relationship between autophagy and radiotherapy.Thus,this review aims to elucidate the effects of autophagy modulations on radio sensitivity and radiotherapy efficacy in various types of cancer.The future development of autophagy modifications for improving radiotherapy efficacy and prognosis of cancer will also be discussed.