免疫功能与超敏C反应蛋白检验对小儿肺炎支原体肺炎的临床价值体会

The clinical value of immunological function and hypersensitive C-reactive protein test on mycoplasma pneumoniae pneumonia in children

目的:探讨免疫功能与超敏C反应蛋白检验(hs-CRP)对小儿肺炎支原体肺炎(MPP)的临床价值体会?方法:选择我院2016年12月~2017年12月收治的98例支原体肺炎患儿为研究对象,以随机数字表法将其分轻度患儿组和重度患儿组,每组各有49例患儿,另外选择同一时期内49例健康儿童作为参照组,采用速率散射比浊法对所有儿童血清中TNF-α(肿瘤坏死因子-α)、IL-6(白细胞介素-6)、hs-CRP(超敏C反应蛋白水平)、免疫球蛋白(lgA、lgM、lgG)、C3(补体C3)、C4(补体C4)进行检测,并对结果进行记录分析.分析免疫功能与超敏C反应蛋白检验对小儿肺炎支原体肺炎的临床价值.结果:三组儿童血清中TNF-α、IL-6、 检测结果比较,重症患儿组TNF-α=(26.21±21.16)pg/mL、IL-6=(49.03±19.26)pg/mL,轻症患儿组TNF-α=(49.03±19.26)pg/mL、IL-6=(35.02±9.97)pg/mL,参照组儿童TNF-α=(9.98±3.25)pg/mL、IL-6=(12.46±3.78)pg/mL;三组儿童免疫球蛋白检测结果比较,重症患儿组lgA=(1.06±0.79)g/L、lgM=(2.72±0.74)g/L、lgG=(12.30±3.13)g/L,轻症患儿组lgA=(1.51±0.56)g/L、lgM=(1.40±0.65)g/L、lgG=(9.78±2.76)g/L,参照组lgA=(1.81±0.81)g/L、lgM=(1.01±0.50)g/L、lgG=(6.85±2.01)g/L;三组儿童的超敏C反应蛋白水平对比:重症患儿组C3=(48.53±2.31)%、C4=(24.20±2.16)%、hs-CRP=(44.51±23.20)mg/L,轻症患儿组C3=(60.54±2.29)%、C4=(34.25±3.34)%、hs-CRP=(20.15±15.41)mg/L,参照组C3=(73.65±4.37)%、C4=(43.26±4.25)%、hs-CRP=(7.30±2.98)mg/L,对三组儿童血清中TNF-α、IL-6、hs-CRP、lgA、lgM、lgG、C3、C4进行两两对比,P均小于0.05,差异具有分析价值.结论:免疫功能与超敏C反应蛋白联合检验能够准确的检验出MPP的发展情况,在后续的治疗中,具有非常高的参考价值,同时,也能够做临床疗效评价指标,具有一定的临床应用意义?

Objective: To study the cEnical value of immune function and hypersensitive C-reactive protein test (hs-CRP) of pediatric mycoplasma pneumoniae pneumonia (MPP). Methods: 98 cases of children with mycoplasma pneumonia from January 2016 to January 2017 were chosen as the research object;with random number table method to differentiate the children with mild and severe children group (49 cases in each group). 49 cases of healthy children were chosen as control group, the rate of scattering turbidimetry for all children in serum TNF alpha (tumor necrosis factor alpha), IL-6 (interleukin 6), the hs-CRP (hypersensitive C-reactive protein levels), immunoglobulin (the IgA, IgM, IgG), the C3 (C3), C4 (complement C4) for testing, and the results were analyzed The clinical value of immune function and hypersensitive C-reactive protein testing of pediatric mycoplasma pneumoniae pneumonia were analyzed. Results:the three groups of children in serum TNF alpha, IL-6, test results, comparison, children with severe set of TNF alpha =(26.21 ± 21.16) pg/mL, IL-6=(49.03±19.26) pg/mL, the children with mild group of TNF alpha =(49.03+19.26) pg/mL, IL-6=(35.02+9.97) pg/mL, TNF-q=(9.98±3.25) pg/mL and il-6 =(12.46±3.78) pg/mL in the control group. After the comparison of three groups of children immune globulin test results, the IgA children with severe group (1.06±0.79)=g/L, IgM=(2.72±0.74)g/L, IgG=(12.30±3.13g/L, the IgA children with mild group (1.51±0.56)=g/L, IgM=(1.40 ±0.65) g/L, IgG=(9.78±2.76g/L, G/L, IgM=(1.01 ±0.50) g/L, IgG=(6.85 ±2.01) g/L, Comparison of hypersensitive C-reactive protein levels in three groups of children: Children with severe set of C3, C4=(48.53±2.31)%(24.20±2.16)%, hs CRP=(44.51±23.20mg/L), children with mild group of C3, C4=(60.54±2.29)%(34.25±334)%, hs CRP=(20.15±15.41 mg/L), control group C3, C4 =(73.65±4.37)%(43.26±4.25)%, hs-CRP=(7.30±2.98mg/L, For three groups of children in serum TNF alpha, IL-6, the hs-CRP, IgA, IgM, IgG, C3, C4 were compared with each group, P vale was less than 0.05, the difierence was significant.Conclusion: the immune function and hypersensitive C-reactive protein test could accurately assess the development of children with mycoplasma pneumonia, in the subsequent treatment, which has very high reference value. At the same time, it could be treated as a clinical efficacy evaluation index in treatment.