基于“外象内感”理论的抽动障碍中医病因及围产期危险因素

Analysis of traditional Chinese medicine causes of tic disorders and its perinatal risk factors based on theory of “Waixiang Neigan”

目的探讨抽动障碍(tic disorders,TD)中医病因及围产期危险因素。方法基于中医先天因素以及"外象内感"理论分析围产期相关的TD中医病因。纳入上海交通大学医学院附属新华医院2015年7月—2016年1月的TD患者128名,对母亲围产期情况进行回顾性分析,明确危险因素。结果 TD的发生与围产期状态相关,母亲围产期的营养不良是引起胎儿长大后罹患TD的危险因素,TD的母亲围产期营养不良是营养均衡者的9. 61倍(95%CI:1. 20～76. 97)。结论围产期异常相关的先天因素为TD重要病因,母亲营养不良是引起胎儿长大后患病的危险因素,应该在此期间注意营养的均衡。

Objective To investigate the traditional Chinese medicine (TCM) etiology of tic disorders(TD) and perinatal risk factors. Methods Based on the TCM congenital factors and the theory of “Waixiang Neigan”, the etiology of perinatal related TD was analyzed. A total of 128 patients with TD were enrolled in Xinhua Hospital, Shanghai Jiao Tong University School of Medicine from July 2015 to January 2016. And then the perinatal risk factors were analyzed and compared with those of healthy children. Results Malnutrition in the perinatal period of mothers was a risk factor for TD. The perinatal malnutrition of TD mothers was 9.61 times higher than that of the balanced nutrition group. The value of 90% CI was 1.20 - 76.97. Conclusion The congenital factors related to perinatal abnormalities are important etiologies of TD. Maternal malnutrition is a risk factor that causes the fetus to become ill and the balance of nutrition should be paid attention to during this period.