异丙托溴铵雾化吸入辅助治疗儿童哮喘的可行性

Feasibility of aerosol inhalation of ipratropium bromide in adjuvant treatment of children with asthma

目的探讨异丙托溴铵雾化吸入辅助治疗儿童哮喘的可行性。方法选择2016年12月～2018年6月于我院确诊哮喘并进行治疗的患儿130例,按照随机对照分类法分为研究组(n=73)和对照组(n=57)。对照组患儿采用布地奈德加沙丁胺醇雾化吸入进行治疗,而研究组在此基础上加用异丙托溴铵。治疗一周后观察两组患者治疗效果、症状评分、肺功能评价指标、嗜酸性粒细胞百分比、C反应蛋白及血清Ig E指标及不良反应发生情况之间的差异。结果实验组患者治疗好转率明显高于对照组(P <0.05);实验组患者治疗后咳嗽及哮鸣音症状评分明显低于对照组(P <0.05),但两组患者喘息症状评分差异无统计学意义(P>0.05);实验组患者治疗后FEV1,PEF及FEV1/FVC均明显高于对照组(P <0.05);实验组患者治疗后Eos%、CRP及Ig E指标均明显低于对照组(P <0.05);两组患儿治疗中均未出现不良反应。结论异丙托溴铵雾化吸入辅助用于儿童哮喘治疗能有效缓解患者症状,缩短治疗周期,其临床应用效果较好,值得推广。

Objective To explore the feasibility of aerosol inhalation of ipratropium bromide in adjuvant treatment of children with asthma.Methods 130 children with asthma who were diagnosed and treated in our hospital from December 2016 to June 2018 were selected.They were divided into study group(n=73)and control group(n=57)according to the randomized controlled classification method.Children in the control group were treated with aerosol inhalation of budesonide and salbutamol.Children in the study group were treated with ipratropium bromide on basis of it.After one week of treatment,the differences in curative effects,symptom score,evaluation index of lung function,eosinophil percentage,C-reactive protein,serum IgE and adverse reactions between the two groups were observed.Results The improvement rate of treatment in the experimental group was significantly higher than that of the control group(P<0.05).The scores of cough and wheezing symptoms in the experimental group were significantly lower than those in the control group(P<0.05),but there was no significant difference in the asthmatic symptom score between the two groups(P>0.05).After treatment,FEV1,PEF and FEV1/FVC in the experimental group were all ignificantly higher than those in the control group(P<0.05).After treatment,Eos%,CRP and IgE indexes in the experimental group were all significantly lower than those in the control group(P<0.05).No adverse reactions occurred in the treatment of children in the two groups.Conclusion Aerosol inhalation of ipratropium bromide in adjuvant treatment of children with asthma can effectively relieve the symptoms of patients and shorten the treatment cycle.The clinical application effect is better and it is worth promoting.