复方多花黄精混合提取物的降血脂作用

Hypolipidemic Effect of Polygonatum cyrtonema Prescription Extract

目的:研究复方多花黄精混合提取物(FHT)对大鼠血脂的影响,为保健食品开发提供理论依据。方法:将65只SD雌性大鼠随机分成空白组,模型组,辛伐他汀阳性组(2 mg/kg),FHT高剂量(30 g生药/kg)、中剂量(15 g生药/kg)、低剂量组(7.5 g生药/kg)。空白组喂全价营养颗粒饲料,其余各组喂养高脂饲料并给予相应的药物灌胃,连续42 d。分别在第二周、第四周、第六周后,眼内眦采血,测定血清总胆固醇(TC)、血清甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)水平。结果:与模型组比较,FHT高剂量组在给药第二周后就能显著性降低TC和TG的水平(p <0.05),在给药第四周后能极显著地降低LDL-C水平和升高HDL-C水平(p <0.01); FHT中低量组在给药第四周后能显著改善TC、TG、LDL-C、HDL-C水平(p <0.05)。结论:FHT具有降血脂作用。

Objective: To study the effect of Polygonatum cyrtonema prescription extract on blood lipid in rats so as to provide basis for the development of health-care food. Methods: 65 female SD rats were randomly divided into control group,model group,positive group (simvastatin,2 mg/kg) and Polygonatum cyrtonema prescription extract groups (30,15,7.5 g/kg). The control group was fed granulated forage,the other groups were fed high fat diet and given the corresponding drug gavage for42 days. The levels of serum total cholesterol (TC),serum triglyceride (TG),low density lipoprotein (LDL-C),high density lipoprotein (HDL) were measured at the 2 nd,4 th and 6 th week after the blood was drawn from inner canthus.Results: Compared with the model group,the high dose group of Polygonatum cyrtonema prescription extract could significantly decrease the level of TC and TG after 2 weeks (p < 0.05),significantly decreased LDL-C level and elevated HDL-C level after 4 weeks (p <0.01).The level of TC,TG,LDL-C and HDL-C also improved significantly by middle and low dose groups of Polygonatum cyrtonema prescription extract after 4 weeks (p < 0.05). Conclusion: Polygonatum cyrtonema prescription extract had hypolipidemic effect.