广西五县结直肠癌影响因素的病例对照研究

Case-control study on influencing factors of colorectal cancer in five counties of Guangxi

目的探讨结直肠癌发病的相关危险因素,为广西结直肠癌防治提供科学依据。方法采用以医院为基础的病例对照研究,在广西抽取5个县作为研究现场,采用问卷调查、膳食调查和体格检查等方式收集相关信息,分析结直肠癌发病的影响因素。结果本次调查病例组、对照组各87人,平均年龄分别为(57.83±13.23)岁和(56.79±13.45)岁。对照组人群的重体力劳动强度者所占比例较大,占41.4%;在慢性结直肠炎、劳动强度、身体质量指数等差异均有统计学意义(P<0.05);对照组的高密度脂蛋白高于病例组,病例组的超敏C反应蛋白水平高于对照组,差异均有统计学意义(P<0.01);logistics回归分析结果显示,与轻体力劳动相比,中、重体力劳动可降低结直肠癌的发病风险,OR (95%CI)值分别为0.39(0.16-0.96)和0.41 (0.17-0.98);超重或肥胖、超敏C反应蛋白水平异常可增加结直肠癌的发病风险,OR (95%CI)值分别为5.74 (1.59-20.72)和30.854 (3.99-238.84)。结论增加体力劳动强度是结直肠癌发病的保护因素,超敏C反应蛋白水平升高以及超重、肥胖可能增加结直肠癌的发病风险。

Objective To explore the risk factors of colorectal cancer in Guangxi and provide scientific evidence for the prevention and treatment of intestinal cancer in Guangxi.Methods A hospital-based case-control study was conducted in five counties in Guangxi as a research site.Questionnaires,dietary surveys,and physical examinations were used as survey methods to collect relevant information and analyze the influencing factors of colorectal cancer.Results There were 87 patients in the case group and the control group.The average age of the two groups was(57.83±13.23) years old and(56.79±13.45) years old.The proportion of heavy physical labor in the control group was relatively large,accounting for 41.4%.There were significant differences between the two groups in chronic colorectal inflammation,labor intensity and body mass index(P<0.05).The high-density lipoprotein in the control group was higher than that in the case group.The level of high-sensitivity C-reactive protein in the case group was higher than that in the control group,and the difference was statistically significant(P <0.01).The logistics regression analysis showed that moderate and heavy physical labor can reduce the risk of colorectal cancer compared with light physical labor.The OR(95% CI)values were 0.39(0.16-0.96)and 0.41(0.17-0.98),respectively.Overweight or obesity,high-sensitivity C-reactive protein levels can increase the risk of colorectal cancer,OR(95% CI)values of 5.74(1.59-20.72)and30.854(3.99-238.84).Conclusion Increasing physical labor intensity is a protective factor for the onset of intestinal cancer.The increased levels of hypersensitive C-reactive protein or overweight and obesity may increase the risk of intestinal cancer.