健脾补肾利水方降低肝硬化腹水患者腹水量的临床研究

Clinical study of Jianpi Bushen Lishui Recipe on reducing ascites volume in patients with ascites due to cirrhosis

目的:观察健脾补肾利水方对肝硬化腹水患者肝前、脾肾间隙、肝肾间隙、下腹部腹水量的影响,评价该方治疗肝硬化腹水的临床疗效。方法:将138例肝硬化腹水患者随机分为观察组和对照组,每组各69例,至研究结束观察组脱落2例,对照组脱落1例。对照组给予西医基础治疗,观察组在此基础上服用健脾补肾利水方,疗程为1月,随访1月。结果:①与治疗前相比,观察组治疗15d、治疗1月及随访1月体重、腹围均降低(P<0.05),且观察组治疗15d、治疗1月及随访1月体重、腹围均显著低于同时期对照组(P<0.05);②与治疗前相比,观察组治疗15d、治疗1月及随访1月肝前、下腹部腹水量均降低(P<0.05),观察组治疗1月、随访1月肝前、下腹部腹水量显著低于同时期对照组(P<0.05);③与治疗前相比,观察组治疗15d、治疗1月及随访1月脾肾间隙、肝肾间隙腹水量均降低(P<0.05),观察组治疗15d、随访1月脾肾间隙、肝肾间隙腹水量显著低于同时期对照组(P<0.05);④与治疗前相比,观察组治疗15d、治疗1月及随访1月腹水指数降低(P<0.05),观察组治疗1月、随访1月腹水指数低于同时期对照组(P<0.05)。结论:健脾补肾利水方可降低肝硬化腹水患者体重、腹围及肝前、脾肾间隙、肝肾间隙、下腹部腹水量,并能降低腹水指数,提高肝硬化腹水患者生存质量。

Objective:To observe the effect of Jianpi Bushen Lishui Recipe on reducing ascites volume in patients with ascites due to cirrhosis.Methods:One hundred and thirty-eight cases of liver cirrhosis were randomly divided into observation group and control group,69 cases in each group,to the end of the study,two cases were lost in the observation group and one cases in the control group.the control group was given the basic treatment of Western medicine,the observation group were taken Jianpi Bushen Lishui Recipe based on the treatment of control group,treatment for one months,followed up for one months.Results:①The body weight and abdominal circumference in the observation group at the fifteenth days,the following months,and the follow-up period of one months decreased compared with that before treatment(P<0.05). The body weight and abdominal circumference in the observation group at the fifteenth days,the following months,and the follow-up period of one months decreased compared with that in the control group at the same period(P<0.05).②The pre-hepatic and hypogastrium ascites volume in the observation group at the fifteenth days,the following months,and the follow-up period of one months decreased compared with that before treatment(P<0.05). The pre-hepatic and hypogastrium ascites volume in the observation group at the following month and the follow-up period of one months decreased compared with that in the control group at the same period(P<0.05).③The ascites volume of splenic and renal space,hepatic and renal space in the observation group at the fifteenth days,the following months,and the follow-up period of one months decreased compared with that before treatment(P<0.05). The ascites volume of splenic and renal space,hepatic and renal space in the observation group at the fifteenth days and the follow-up period of one months decreased compared with that in the control group at the same period(P<0.05).④The index of ascites in the observation group at the fifteenth days,the following months,and the follow-up period of one months decreased compared with that before treatment(P<0.05). The index of ascites in the observation group at the following months,and the follow-up period of one months decreased compared with that in the control group at the same period(P<0.05).Conclusion:Jianpi Bushen Lishui Recipe can reduce the body weight,abdominal circumference,and the ascites volume in pre-hepatic,splenic and renal space,hepatic and renal space,and hypogastrium in patients with cirrhosis ascites,and can reduce the index of ascites,improve the quality of life with cirrhosis ascites.