青海省人群维生素D水平与甲状腺过氧化物酶水平的关系

Relationship between vitamin D level and thyroid peroxidase level in Qinghai Province

目的探讨青海省人群维生素D水平与甲状腺过氧化物酶(TPO)水平的关系。方法2015、2016年,采取分层整群抽样方法抽取青海省9个地区人群1 873例,其中男性935人、女性938人,年龄为(52.3 ± 10.9)岁,汉族1 040人、藏族833人。采集人群空腹静脉血,采用全自动化学发光免疫分析系统检测维生素D和TPO水平,分析不同性别、民族、海拔高度人群维生素D和TPO水平。结果人群维生素D水平为(16.3 ± 7.5)μg/L,维生素D异常率为89.2%(1 670/1 873);TPO水平[中位数(四分位数)]为23.8(16.0 ~ 35.0)U/ml,TPO阳性率为26.8%(502/1 873)。男、女性维生素D水平分别为(16.9 ± 7.6)、(15.6 ± 7.6)μg/L,二者比较差异有统计学意义(t = 3.684,P < 0.01);TPO水平分别为23.8(16.4 ~ 31.0)、23.8(15.9 ~ 37.6)U/ml,二者比较差异无统计学意义(Z =- 1.084,P > 0.05)。汉族、藏族人群维生素D水平分别为(16.2 ± 7.8)、(16.3 ± 7.3)μg/L,二者比较差异无统计学意义(t =- 0.110,P > 0.05);TPO水平分别为23.5(15.7 ~ 34.8)、24.0(16.5 ~ 35.1)U/ml,二者比较差异无统计学意义(Z =- 0.078,P > 0.05)。中海拔(1 500 ~ 3 000 m)、高海拔(> 3 000 m)人群维生素D水平分别为(16.6 ± 7.7)、(15.8 ± 7.5)μg/L,二者比较差异无统计学意义(t = 2.126,P > 0.05);TPO水平分别为23.4(16.0 ~ 33.0)、24.0(16.0 ~ 36.8)U/ml,二者比较差异无统计学意义(Z =- 1.296,P > 0.05)。维生素D水平与TPO水平、海拔高度呈负相关(r =- 0.150、- 0.052,P均< 0.05),与民族未见相关性(r = 0.003,P > 0.05)。结论青海地区人群维生素D水平与TPO水平呈负相关,且维生素D异常率高,男性维生素D水平高于女性。

Objective To investigate the relationship between vitamin D level and thyroid peroxidase (TPO) level in Qinghai Province. Methods In 2015 and 2016, a stratified cluster sampling method was used to select 1 873 people in 9 regions of Qinghai Province, including 935 males and 938 females, the average age was (52.3 ± 10.9) years old, there were 1 040 Han people and 833 Tibetans. Fasting venous blood samples were collected, and vitamin D and TPO levels were detected by a fully automated chemiluminescence immunoassay system, vitamin D and TPO levels were compared in different gender, ethnic group, and altitude populations. Results The vitamin D level was (16.3 ± 7.5)μg/L, and abnormal rate of vitamin D was 89.2%(1 670/1 873);the TPO level [median (quartile)] was 23.8 (16.0 - 35.0) U/ml, and the positive rate of TPO was 26.8%(502/1 873). The vitamin D levels of males and females were (16.9 ± 7.6) and (15.6 ± 7.6)μg/L, respectively, the difference was statistically significant (t = 3.684, P < 0.01);the TPO levels were 23.8 (16.4 - 31.0) and 23.8 (15.9 - 37.6) U/ml, respectively, the difference was not statistically significant (Z =- 1.084, P > 0.05). The vitamin D levels of the Han people and the Tibetans were (16.2 ± 7.8) and (16.3 ± 7.3)μg/L, respectively, the difference was not statistically significant (t =- 0.110, P > 0.05);the TPO levels were 23.5 (15.7 - 34.8) and 24.0 (16.5 - 35.1) U/ml, respectively, the difference was not statistically significant (Z =- 0.078, P > 0.05). The vitamin D levels of middle-altitude (1 500 - 3 000 m) and high-altitude (> 3 000 m) populations were (16.6 ± 7.7) and (15.8 ± 7.5)μg/L, respectively, and the difference was not statistically significant (t = 2.126, P > 0.05);the TPO levels were 23.4 (16.0 - 33.0) and 24.0 (16.0 - 36.8) U/ml, respectively, the difference was not statistically significant (Z =- 1.296, P > 0.05). There was negative correlations between vitamin D level and TPO level, altitude (r =- 0.150,- 0.052, P < 0.05), and no correlation with ethnic group (r = 0.003, P > 0.05). Conclusions The vitamin D level is negatively correlated with TPO level in Qinghai population. The abnormal rate of vitamin D is high, and vitamin D level of males is higher than that of females.