血清8-iso-PGF_(2α)、ET-1水平与OSAHS患者合并认知功能障碍的相关性

The correlations between serum 8-iso-PGF_(2α) and ET-1 levels and cognitive dysfunction in patients with obstructive sleep apnea hypopnea syndrome

目的探讨8异构前列腺异素F2α(8-iso-Prostaglandin F2α, 8-iso-PGF_(2α))和内皮素-1(endothelin-1, ET-1)水平与阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome, OSAHS)患者合并认知功能障碍的相关性,为干预OSAHS患者并发认知功能障碍提供新的临床依据。方法选取86例OSAHS患者,依据蒙特利尔认知评估量表(montreal cognitive as-sessment, MoCA)的评分标准将其分为认知障碍组及认知正常组,选取同期门诊健康体检者50例作为对照组,分析血清8-iso-PGF_(2α)、ET-1水平与认知功能的相关性,以及血清8-iso-PGF_(2α)、ET-1水平预测认知障碍的受试者工作特征(ROC)曲线。结果认知障碍组患者血清8-iso-PGF_(2α)、ET-1水平[分别为(581.34±271.72)pg/mL、(121.75±74.15)pg/mL]高于认知正常组[(401.21±173.94)ng/mL、(76.42±39.92)pg/mL],差异均有统计学意义(P<0.05)。认知障碍组血清8-iso-PGF_(2α)及ET-1水平与MoCA评分总分及其亚项评分均呈负相关;且8-iso-PGF_(2α)与ET-1呈正相关。制作OSAHS患者认知功能障碍的ROC曲线,8-iso-PGF_(2α)和ET-1曲线下面积分别为0.724及0.743。结论 OSAHS患者血清中8-iso-PGF_(2α)、ET-1水平与认知障碍呈负相关,且血清中8-iso-PGF_(2α)、ET-1水平可以预测认知功能损伤,两者均有较强的特异度。

Objective To investigate the correlations between 8-iso-PGF2α and ET-1 levels and cognitive function in patients with obstructive sleep apnea hypopnea syndrome(OSAHS), and to provide new evidence for intervention in OSAHS patients with cognitive impairment. Methods Eighty-six OSAHS patients were divided into cognitive dysfunction group and cognitive normal group according to the Montreal cognitive assessment scale. The correlations between the levels of ET-1 and 8-iso-PGF2α and cognitive function were analyzed. The receiver operating characteristic(ROC) curves of serum 8-iso-PGF2α, ET-1 levels in predicting cognitive impairment were calculated. Results The levels of serum 8-iso-PGF2α and ET-1 in OSAHS patients with cognitive impairment [(581.34±271.72) pg/mL and(121.75±74.15) pg/mL] were significantly higher than those in the cognitive normal group [(401.21±173.94) ng/mL and(76.42±39.92) pg/mL, P<0.05]. Serum 8-iso-PGF2α and ET-1 levels were significantly negatively correlated with MoCA score and subitem scores. And 8-iso-PGF2α was significantly positively correlated with ET-1. The areas under ROC curves of 8-iso-PGF2α and ET-1 in predicting cognitive impairment in OSAHS patients were 0.724 and 0.743, respectively. Conclusion The 8-iso-PGF2α and ET-1 levels in serum of OSAHS patients are negatively correlated with cognitive impairment. They can predict cognitive impairment, with strong specificity.