摘要
膝骨关节炎是中老年人常见病、多发病,其病因病机尚不十分清楚。从文献理论阐述以毒论治膝骨关节炎的理论基础,提出"内毒和外毒"是膝骨关节的基本病机。从炎症因子与蛋白及信号通路角度,总结以毒瘀论治膝骨关节炎的作用机制,提出白细胞介素-1、6(IL-1、6)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶/基质金属蛋白酶抑制剂(MMPs/TIMPs)等为其可能的作用机制。旨在为今后以毒论治膝骨关节炎临床治疗和实验研究提供参考,为防治膝骨关节炎具有一定的临床意义。
Knee osteoarthritis is a common and frequently-occurring disease in old people,but the etiology and pathogenesis is still unclear. From the literature theory it expounded on the basis of the theory of drug treatment knee osteoarthritis,put forward the "poison inside and outside"basic pathogenesis. From the perspective of inflammatory factors and proteins and signaling pathways,it elucidated the mechanism of knee osteoarthritis,interleukin 1 and 6( IL-1,IL-6),tumor necrosis factor alpha( TNF-alpha),matrix metalloproteinases/matrix metalloproteinases inhibitor( MMPs/TIMPs) for its possible mechanism,which have certain clinical significance for prevention and treatment of knee osteoarthritis.
作者
邝高艳
严可
卢敏
谭旭仪
龚志贤
吴泳蓉
KUANG Gaoyan;YAN Ke;LU Min;TAN Xuyi;G0NG Zhixian;WU Yongrong(The 1st Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007 , Hunan, China;Hunan University of Chinese Medicine,Changsha 410208 , Hunan,China)
出处
《辽宁中医杂志》
CAS
2019年第3期492-494,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81574004
81874476)
湖南省自然科学基金项目(2018JJ2303)
湖南省科技厅创新项目(2017SK50302)
湖南省中医药科研计划项目(2017149
2017146)
湖南省教育厅课题项目(17C1224)
湖南中医药大学校级课题(ZYYDX201726
2018XJJJ39)
关键词
膝骨关节炎
以毒瘀论治
病机
knee osteoarthritis ( KOA)
toxin and blood stasis
pathogenesis analysis