从毒瘀论治膝骨关节炎及毒瘀本质的分析

Characteristic of TCM Pathogenesis “Toxin and Blood Stasis”of KOA and Analysis of Essence

膝骨关节炎是中老年人常见病、多发病,其病因病机尚不十分清楚。从文献理论阐述以毒论治膝骨关节炎的理论基础,提出"内毒和外毒"是膝骨关节的基本病机。从炎症因子与蛋白及信号通路角度,总结以毒瘀论治膝骨关节炎的作用机制,提出白细胞介素-1、6(IL-1、6)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶/基质金属蛋白酶抑制剂(MMPs/TIMPs)等为其可能的作用机制。旨在为今后以毒论治膝骨关节炎临床治疗和实验研究提供参考,为防治膝骨关节炎具有一定的临床意义。

Knee osteoarthritis is a common and frequently-occurring disease in old people,but the etiology and pathogenesis is still unclear. From the literature theory it expounded on the basis of the theory of drug treatment knee osteoarthritis,put forward the "poison inside and outside"basic pathogenesis. From the perspective of inflammatory factors and proteins and signaling pathways,it elucidated the mechanism of knee osteoarthritis,interleukin 1 and 6( IL-1,IL-6),tumor necrosis factor alpha( TNF-alpha),matrix metalloproteinases/matrix metalloproteinases inhibitor( MMPs/TIMPs) for its possible mechanism,which have certain clinical significance for prevention and treatment of knee osteoarthritis.